DataVXACS Applied Materials & InterfacesPaper
journal article·2025-12-17

NIR-Responsive Free Standing Borophene Mediates Photothermal and Photodynamic Therapy to Reduce Bacterial Biofilm Burden

Antony Vincy, Vishakha Anand, Dinesh Kumar Kannan, Anup Pandith, Bharat Gurnani, Pranay Ranjan, Arjun Pathak, Neha Jain, Sumit Chahal, Prashant Kumar, Raviraj Vankayala

ACS Applied Materials & Interfaces· Volume 17· Issue 50
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Source abstract

Abstract

Bacterial biofilms in open clinical wounds drive persistent infections, antibiotic resistance, and chronic inflammation, posing significant treatment challenges. Traditional therapies, including surgical debridement and antibiotics, are increasingly ineffective due to resistant strains. Light-activatable photosensitizers offer promise but are limited by poor tissue penetration and rapid photobleaching, especially in the UV/visible spectrum. Here, we introduce free-standing borophene nanosheets (B NSs) as a photoactivatable nanomaterial operating within the NIR-I and NIR-II biological windows. The B NSs demonstrate high photothermal conversion efficiencies (∼32% in NIR-I, 26.3% in NIR-II) and efficiently generate singlet oxygen under NIR irradiation. Functionally, B NSs effectively inhibit biofilm formation and eradicate mature biofilms ex vivo, while exhibiting minimal toxicity in vivo in a zebrafish model. These findings highlight B NSs as a promising, noninvasive approach for combating antibiotic-resistant biofilms with potential for clinical translation.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Carbon and Quantum Dots Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioscience and Bioengineering

Indian Institute of Technology Jodhpur

Graduate Institute of Biomaterials and Tissue Engineering (GIBMTE), College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 235603, Taiwan R.O.C.

International Ph.D. Program in Biomedical Engineering (IPBME), College of Biomedical Engineering, Taipei Medical University, Shuang-Ho Campus, New Taipei City 235603, Taiwan R.O.C.

Centre of Excellence-AyurTech

Department of Metallurgical and Materials Engineering

Department of Physics

Indian Institute of Technology Hyderabad, Kandi

Department of Applied Sciences, School of Advanced Engineering, University of Petroleum and Energy Studies, Energy Acres, Bidholi Campus, P.O. Bidholi, Via Prem Nagar, Uttarakhand 248007, India

Global Innovative Centre for Advanced Nanomaterials (GICAN)

University of Newcastle

Interdisciplinary Research Division Smart Healthcare

Funding

Ministry of Electronics and Information technology · Science and Engineering Research Board · Department of Biotechnology, Ministry of Science and Technology, India · Indian Institute of Technology Jodhpur · Taipei Medical University Hospital · Ministry of AYUSH, Government of India · National Science and Technology Council · Ministry of Education, Taiwan

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