Enhancing Mechanical Durability of Water-Soluble Microneedles with Cellulose Nanofibers via Thermal Imprinting
Source abstract
Abstract
The study demonstrates the effectiveness of ultrahigh-pressure homogenizer (UHPH) cellulose nanofibers (CNFs) in improving the mechanical properties of poly(vinyl alcohol) (PVA) microneedle arrays (MNA). CNFs were incorporated into PVA nanocomposite films at concentrations of 0, 5, and 8 wt % using solvent casting and a nickel mold coated with a fluoropolymer was used to thermally imprint the films with MNA micropatterns at optimal mold temperatures and pressing pressure. The integration of CNFs substantially enhanced the morphological properties, surface modulus, and the accuracy of pattern replication in the nanocomposite. The augmented mechanical strength observed in the micropatterns, attributed to CNFs and subjected to UHPH treatment, can be ascribed to the physical entanglement and hydrogen bonding facilitating formation within the MNA micropattern.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Cellulose Research Studies · Advancements in Transdermal Drug Delivery · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate School of Organic Materials Science, Yamagata University, 4-3-16, Jonan, Yonezawa 992-8510, Yamagata,Japan
Research Center for Green Materials and Advanced Processing, Yamagata University, 4-3-16, Jonan, Yonezawa 992-8510, Yamagata, Japan
Funding
Japan Science and Technology Agency
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