Merged Red and NIR Light Sources for Photobiomodulation Therapy in Diabetic Wound Healing

Photobiomodulation (PBM) is considered an effective and safe therapeutic modality in supporting the treatment of complications from a global pandemic-diabetes. In this study, PBM therapy is investigated to accelerate wound healing in diabetic mice (DM), under the combined biological effects of red light from a red organic light-emitting diode (ROLED) and near-infrared (NIR) light from an NIR conversion film (NCF) with dispersed CuInS 2 /ZnS quantum dots (QDs). The QD concentration and the NCF structure were optimized to maximize the optical properties and mechanical stability. A merged red/NIR device (MRND) was produced by integrating the optimized NCF and ROLED for PBM therapy. As a result of irradiating DM with MRND at a dose of 2 J/cm 2, after 10 days, the wounds recovered three times faster than DM without MRND. Additionally, MRND light not only restored the epidermal thickness to normal but also significantly reduced the levels of pro-inflammatory cytokines. The experimental results show that the proposed PBM therapy has the potential to improve the quality of life of diabetic patients by helping them with rapid wound healing.