Phototriggered N2-Generating Submicron Particles for Selective Killing of Cancer Cells
Source abstract
Abstract
Killing of cancer cells by applying mechanical disruption has been an appealing emerging strategy for cancer treatment in recent years. In this study, photoresponsive submicron particles based on diazo-resin that are able to release N 2 under UV irradiation were prepared through a polyamine–salt aggregation method. After surface modification with hyaluronic acid, the particles could be internalized selectively by cancer cells and were mainly located in lysosomes after 6 h incubation. The viability of cancer cells decreased obviously after they were co-cultured with photoresponsive particles and UV irradiation due to the integrity damage of lysosomes by phototriggered N 2 generation and the subsequent increased number of reactive oxygen species.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Surface Modification and Superhydrophobicity · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University in Hangzhou, Hangzhou 310027, China
Funding
Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · Zhejiang Province
References (35)
Show source-provided references
1. 10.1016/j.ccr.2007.03.01210.1016/j.ccr.2007.03.012 ↗
2. 10.1038/nmat299210.1038/nmat2992 ↗
3. 10.1002/anie.20100324410.1002/anie.201003244 ↗
4. 10.1021/nn200478m10.1021/nn200478m ↗
5. 10.1002/anie.20120548210.1002/anie.201205482 ↗
6. 10.1002/adfm.20140440210.1002/adfm.201404402 ↗
7. 10.1021/la991482z10.1021/la991482z ↗
8. 10.1039/a804623i10.1039/a804623i ↗
9. 10.1021/la048093b10.1021/la048093b ↗
10. 10.1002/ppsc.20130024610.1002/ppsc.201300246 ↗
11. 10.1002/1616-3028(200104)11:2<122::AID-ADFM122>3.0.CO;2-N10.1002/1616-3028(200104)11:2<122::AID-ADFM122>3.0.CO;2-N ↗
12. 10.1021/am401638910.1021/am4016389 ↗
13. 10.1039/C2NR32145A10.1039/C2NR32145A ↗
14. 10.1021/bc300349n10.1021/bc300349n ↗
15. 10.1039/c1jm10712g10.1039/c1jm10712g ↗
16. 10.1002/(SICI)1097-4628(19980906)69:10<1975::AID-APP9>3.0.CO;2-B10.1002/(SICI)1097-4628(19980906)69:10<1975::AID-APP9>3.0.CO;2-B ↗
17. 10.1074/jbc.M60835820010.1074/jbc.M608358200 ↗
18. 10.1021/nn201643f10.1021/nn201643f ↗
19. 10.1016/S0022-1759(02)00070-410.1016/S0022-1759(02)00070-4 ↗
20. 10.1016/j.colsurfb.2016.02.06010.1016/j.colsurfb.2016.02.060 ↗
21. 10.1016/j.jconrel.2006.07.02110.1016/j.jconrel.2006.07.021 ↗
22. 10.1021/jacs.6b0024310.1021/jacs.6b00243 ↗
23. 10.1002/adma.20130273710.1002/adma.201302737 ↗
24. 10.1039/C7MH00420F10.1039/C7MH00420F ↗
25. 10.1038/ncb0509-51010.1038/ncb0509-510 ↗
26. 10.1007/s00018-009-0053-z10.1007/s00018-009-0053-z ↗
27. 10.1021/ja511420n10.1021/ja511420n ↗
28. 10.1021/ja406992w10.1021/ja406992w ↗
29. 10.1039/C6NR02181F10.1039/C6NR02181F ↗
30. 10.1038/nrc107110.1038/nrc1071 ↗
31. 10.1039/C4CC07128J10.1039/C4CC07128J ↗
32. 10.1038/nrc173810.1038/nrc1738 ↗
33. 10.1038/sj.leu.240371710.1038/sj.leu.2403717 ↗
34. 10.1111/j.1751-1097.1990.tb01685.x10.1111/j.1751-1097.1990.tb01685.x ↗
35. 10.1073/pnas.88.4.158010.1073/pnas.88.4.1580 ↗