DataVXACS Applied Materials & InterfacesPaper
journal article·2023-08-23Open access

Self-Assembling Peptide-Appended Metallomacrocycle Pores for Selective Water Translocation

Li-Bo Huang, Fumihiko Mamiya, Marc Baaden, Eiji Yashima, Mihail Barboiu

ACS Applied Materials & Interfaces· Volume 15· Issue 33
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Source abstract

Abstract

Artificial water channels selectively transport water, excluding all ions. Unimolecular channels have been synthesized via complex synthetic steps. Ideally, simpler compounds requesting less synthetic steps should efficiently lead to selective channels by self-assembly. Herein, we report a self-assembled peptide-bound Ni 2+ metallomacrocycle, 1, in which rim-peptide-bound units are connected to a central macrocycle obtained via condensation in the presence of Ni 2+ ions. Compound 1 achieves a single-channel permeability up to 10 7 –10 8 water/s/channel and insignificant ion transport, which is 1 order of magnitude lower than those for aquaporins. Molecular simulations probe that spongelike aggregates can form to generate transient cluster water pathways through the bilayer. Altogether, adaptive metallosupramolecular self-assembly is an efficient and simple way to construct selective channel superstructures.
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Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · Nanopore and Nanochannel Transport Studies · Supramolecular Chemistry and Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut Europeen des Membranes, Adaptive Supramolecular Nanosystems Group, University of Montpellier, ENSCM-CNRS, UMR5635, Place E. Bataillon CC047, Montpellier 34095, France

School of Chemical Engineering and Technology, Hainan University, Haikou 570228, China

Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University Chikusa-ku, Nagoya 464-8603, Japan

Laboratoire de Biochimie Théorique, CNRS, Université Paris Cité, 13 rue Pierre et Marie Curie, Paris F-75005, France

Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University Chikusa-ku, Nagoya 464-8603, Japan

Funding

Agence Nationale de la Recherche

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