DataVXACS Applied Materials & InterfacesPaper
journal article·2022-09-07

Polymeric Nanoreactors with Chemically Tunable Redox Responsivity

Lidong Gong, Changrong Wang, Pengcheng Xu, Jingjing Gong, Chuanda Zhu, Shiming Di, Yanglonghao Li, Yongxu Mu, Hongbin Han, Qiang Zhang, Zhiqiang Lin

ACS Applied Materials & Interfaces· Volume 14· Issue 35
Publisher page
Source abstract

Abstract

Bioresponsive nanomaterials are increasingly important in a variety of applications such as disease imaging, drug delivery, and tissue engineering. However, it remains a big challenge to manipulate response efficacy of such materials for performance optimization in a highly complex milieu in vivo. Here, we developed chemically adjustable nanoreactors (CANs) with the structure of polymeric cores and albumin shells to achieve tunable redox responsivity. In vitro characterization demonstrates stable, spherical nanoparticles of the CANs with a particle size of about 50 nm. The fluorescence activation ratios of the CANs are determined by various albumin modification densities on the shell. Meanwhile, the response sensitivity of the CANs to GSH levels (0.6-4 mM) can be tuned by acid-base properties of polymeric blocks in the core. This unique tunable redox responsivity enables the CANs suitable for probe optimization in cancer imaging both in vivo and at histological levels. Overall, this study offers a new design strategy for manipulation on performance of core/shell nanoreactors or bioresponsive nanomaterials.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Systems Biomedicine, Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P. R. China

Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, Yantai 264003, P. R. China

Department of Pharmaceutical Engineering, College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, P. R. China

The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, P. R. China

Institute of Medical Technology, Beijing Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Peking University Health Science Center, Beijing 100191, P. R. China

Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Funding

Inner Mongolia Autonomous Region · Peking University · Ministry of Education of the People's Republic of China · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Health Science Center, Peking University

References (28)

Show source-provided references
1. 10.1038/natrevmats.2016.7510.1038/natrevmats.2016.75 ↗
2. 10.1002/adma.20200005510.1002/adma.202000055 ↗
3. 10.1021/acs.accounts.9b0016710.1021/acs.accounts.9b00167 ↗
4. 10.1002/advs.20210537310.1002/advs.202105373 ↗
5. 10.1002/smll.20180487810.1002/smll.201804878 ↗
6. 10.1038/s41568-022-00454-510.1038/s41568-022-00454-5 ↗
7. 10.1038/s41568-021-00435-010.1038/s41568-021-00435-0 ↗
8. 10.1002/smtd.20210143710.1002/smtd.202101437 ↗
9. 10.1002/advs.20210344410.1002/advs.202103444 ↗
10. 10.1002/adma.20200729010.1002/adma.202007290 ↗
11. 10.1038/nmat381910.1038/nmat3819 ↗
12. 10.1038/nmat377610.1038/nmat3776 ↗
13. 10.7150/thno.3322810.7150/thno.33228 ↗
14. 10.1038/ncomms1321410.1038/ncomms13214 ↗
15. 10.1021/acsami.9b1106310.1021/acsami.9b11063 ↗
16. 10.1002/adma.20210992010.1002/adma.202109920 ↗
17. 10.1021/acsnano.1c0677710.1021/acsnano.1c06777 ↗
18. 10.1016/j.biomaterials.2021.12130710.1016/j.biomaterials.2021.121307 ↗
19. 10.1021/acsnano.0c0224910.1021/acsnano.0c02249 ↗
20. 10.1186/s12951-020-00603-810.1186/s12951-020-00603-8 ↗
21. 10.1016/j.ccr.2016.07.00710.1016/j.ccr.2016.07.007 ↗
22. 10.1002/adma.20150238910.1002/adma.201502389 ↗
23. 10.1016/j.apcatb.2022.12125510.1016/j.apcatb.2022.121255 ↗
24. 10.1021/acs.chemrev.6b0059610.1021/acs.chemrev.6b00596 ↗
25. 10.1002/anie.20220015210.1002/anie.202200152 ↗
26. 10.1021/ja505315810.1021/ja5053158 ↗
27. Selker H. P. · Trans. Am. Clin. Climatol. Assoc. · 2018 · 129 · 279
28. 10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗