DataVXACS Applied Materials & InterfacesPaper
journal article·2018-08-22Open access

Inhibiting Pathogen Surface Adherence by Multilayer Polyelectrolyte Films Functionalized with Glucofuranose Derivatives

Valeria Villalobos, Ángel Leiva, Hernán E. Ríos, Jorge Pavez, Carlos P. Silva, Mohammed Ahmar, Yves Queneau, J. M. Blamey, Francisco P. Chávez, Marcela D. Urzúa

ACS Applied Materials & Interfaces· Volume 10· Issue 33
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Source abstract

Abstract

Inhibiting pathogenic bacterial adherence on surfaces is an ongoing challenge to prevent the development of biofilms. Multilayer polyelectrolyte films are feasible antibacterial materials. Here, we have designed new films made of carbohydrate polyelectrolytes to obtain antibacterial coatings that prevent biofilm formation. The polyelectrolyte films were constructed from poly(maleic anhydride- alt-styrene) functionalized with glucofuranose derivatives and quaternized poly(4-vinylpyridine) N-alkyl. These films prevent Pseudomonas aeruginosa and Salmonella Typhimurium, two important bacterial contaminants in clinical environments, from adhering to surfaces. When the film was composed of more than 10 layers, the bacterial population was greatly reduced, while the bacteria remaining on the film were morphologically damaged, as atomic force microscopy revealed. The antibacterial capacity of the polyelectrolyte films was determined by the combination of thickness, wettability, surface energy, and most importantly, the conformation that polyelectrolytes adopt the function of nature of the carbohydrate group. This polyelectrolyte film constitutes the first green approach to preventing pathogenic bacterial surface adherence and proliferation without killing the bacterial pathogen.
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Research context

OpenAlex topics: Antimicrobial agents and applications · Polymer Surface Interaction Studies · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Instituto de Ciencias Químicas Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, El Llano Subercaseaux 2801, 8900000 San Miguel, Santiago, Chile

Departamento de Química-Física, Facultad de Química, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, 7820436 Macul, Chile

Departamento de Química de los Materiales, Facultad de Química y Biología, Soft Matter Research-Technology Center, Universidad de Santiago de Chile, SMAT-C, Av. B. O’Higgins 3363, Casilla 40, Correo 33, 1100773 Santiago, Chile

Université de Lyon, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, ICBMS, UMR 5246, CNRS, UCBL, INSA Lyon, CPE Lyon, Bâtiment Lederer, 1 Rue Victor Grignard, 69622 Villeurbanne Cedex, France

Fundación Biociencia, José Domingo Cañas 2280, 7750132 Ñuñoa, Santiago, Chile

Funding

Departamento de Investigaciones Cient?ficas y Tecnol?gicas, Universidad de Santiago de Chile · Comisi?n Nacional de Investigaci?n Cient?fica y Tecnol?gica · Fondo Nacional de Desarrollo Cient?fico y Tecnol?gico

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