DataVXACS Applied Materials & InterfacesPaper
journal article·2020-03-04

Oligodots: Structurally Defined Fluorescent Nanoprobes for Multiscale Dual-Color Imaging in Vitro and in Vivo

Fatemeh Ostadhossein, Dinabandhu Sar, Indu Tripathi, Julio Soares, Edward E. Remsen, Dipanjan Pan

ACS Applied Materials & Interfaces· Volume 12· Issue 9
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Source abstract

Abstract

Nanoscale fluorescent probes are of great importance due to their capabilities for imaging on multiscale. Herein, we report the first synthesis of structurally well-defined nanoparticulate “oligodots” developed for multicolor imaging in vitro and in vivo. These nanoparticles are prepared via condensation and curing reactions where the engineering of the solvent results in the nanoparticles with green (λem = 550 nm) and red (λem = 650 nm) emission range. Differences found in the photophysical properties have been attributed to variations in oligomeric compositions produced during the synthesis as was corroborated by extensive physicochemical characterizations. Specifically, mass spectroscopy provided a picture of the formed species during the synthesis. The feasibility of the oligodots for multicolor imaging is demonstrated both in vitro and in vivo. The red-emitting oligodot is employed for dynamic whole-body imaging in mice. It is envisioned that oligodots would enable multicolor imaging of various biomarkers in complex diseases such as cancer where numerous molecular and metabolic phenotypes work in concert in their emergence.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering, University of Illinois at Urbana—Champaign, 611 West Park Street, Urbana, Illinois 61801, United States

Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, Illinois 61801, United States

Beckman Institute of Advanced Science and Technology, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States

Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States

Mund-Lagowski Department of Chemistry and Biochemistry, Bradley University, Peoria, Illinois 61625, United States

Department of Materials Science and Engineering, University of Illinois at Urbana—Champaign, Urbana, Illinois 61801, United States

Funding

American Heart Association · Children's Discovery Institute · U.S. Department of Defense · National Institutes of Health · University of Illinois at Urbana-Champaign · Beckman Institute

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