DataVXACS Applied Materials & InterfacesPaper
journal article·2018-04-18

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films

Michal M. Dykas, Stuti K. Desai, Abhijeet Patra, Mallikarjuna Rao Motapothula, Kingshuk Poddar, Linda J. Kenney, T. Venkatesan

ACS Applied Materials & Interfaces· Volume 10· Issue 15
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Source abstract

Abstract

With the rise in nosocomial infections worldwide, research on materials with an intrinsic ability to inhibit biofilm formation has been generating a great deal of interest. In the present work, we describe how thin film material libraries generated by pulsed laser deposition can be used for simultaneously screening several novel metal oxide mixtures that inhibit biofilm formation in a common human pathogen, Salmonella enterica serovar Typhimurium. We discovered that in a material library constructed using two metal oxides, the net effect on biofilm formation can be modeled as an addition of the activities of the individual oxides weighted to their relative composition at that particular point on the library. In contrast, for similar material libraries constructed using three metal oxides, there was a nonlinear relation between the amount of dominant metal oxide and the formation of Salmonella biofilms. This nonlinearity resulted in several useful metal oxide combinations that were not expected from the weighted average predictions. Our novel application will lead to the discovery of additional alternatives for creating antimicrobial surfaces.
Source: openalex_inverted_index · Quality: baseline

Research context

Materials processing

OpenAlex topics: Bacterial biofilms and quorum sensing · Nanoparticles: synthesis and applications · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

NUS Nanoscience & Nanotechnology Institute—NanoCore, 5A Engineering Drive 1, 117411, Singapore

NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, 117456, Singapore

Mechanobiology Institute, National University of Singapore (NUS), 5A Engineering Drive 1, 117411, Singapore

Jesse Brown Veterans Affairs Medical Center, 820 S. Damen Avenue, Chicago, Illinois 60612, United States

Department of Microbiology and Immunology, University of Illinois−Chicago, 1853 West Polk Street, Room 130 CMW, Mail Code 784, Chicago, Illinois 60612, United States

Department of Electrical Engineering, National University of Singapore, 4 Engineering Drive 3, 117576, Singapore

Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, 117575, Singapore

Department of Physics, Faculty of Science, National University of Singapore, 2 Science Drive 3, 117551, Singapore

Funding

U.S. Department of Veterans Affairs · Ministry of Education - Singapore · Office of the Deputy President, National University of Singapore · Nanoscience and Nanotechnology Institute, National University of Singapore · Research Centre of Excellence in Mechanobiology, National University of Singapore

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