DataVXACS Applied Materials & InterfacesPaper
journal article·2021-09-22

Nonimmunogenic Hydrogel-Mediated Delivery of Antibiotics Outperforms Clinically Used Formulations in Mitigating Wound Infections

Sandeep Kumar, Sanjay Pal, Jyoti Thakur, Parul Rani, Kajal Rana, Animesh Kar, Raunak Kar, Devashish Mehta, Somesh Kumar Jha, Manas Kumar Pradhan, Dolly Jain, Kajal Rajput, Sarita Mishra, Munia Ganguli, Aasheesh Srivastava, Ujjaini Dasgupta, Veena S. Patil, Avinash Bajaj

ACS Applied Materials & Interfaces· Volume 13· Issue 37
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Source abstract

Abstract

Treatment of chronic wound infections caused by Gram-positive bacteria such as Staphylococcus aureus is highly challenging due to the low efficacy of existing formulations, thereby leading to drug resistance. Herein, we present the synthesis of a nonimmunogenic cholic acid–glycine–glycine conjugate (A6) that self-assembles into a supramolecular viscoelastic hydrogel (A6 gel) suitable for topical applications. The A6 hydrogel can entrap different antibiotics with high efficacy without compromising its viscoelastic behavior. Activities against different bacterial species using a disc diffusion assay demonstrated the antimicrobial effect of the ciprofloxacin-loaded A6 hydrogel (CPF-Gel). Immune profiling and gene expression studies after the application of the A6 gel to mice confirmed its nonimmunogenic nature to host tissues. We further demonstrated that topical application of CPF-Gel clears S. aureus-mediated wound infections more effectively than clinically used formulations. Therefore, cholic acid-derived hydrogels are an efficacious matrix for topical delivery of antibiotics and should be explored further.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Wound Healing and Treatments · Antimicrobial Peptides and Activities · Antimicrobial agents and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Nanotechnology and Chemical Biology, Regional Centre for Biotechnology, NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121001, Haryana, India

Department of Chemistry, Indian Institute of Science Education and Research, Bhopal By-pass Road, Bhauri, Bhopal 462030, India

National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India

Amity Institute of Integrative Sciences and Health, Amity University Haryana, Panchgaon, Manesar, Gurgaon 122413, Haryana, India

CSIR-Institute of Genomics and Integrative Biology, New Delhi 110025, India

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India

Funding

Department of Biotechnology , Ministry of Science and Technology · Regional Centre for Biotechnology · Department of Science and Technology, Ministry of Science and Technology

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