DataVXACS Applied Materials & InterfacesPaper
journal article·2018-08-01Open access

Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies

Witold I. Tatkiewicz, Joaquin Seras-Franzoso, Elena Garcia-Fruitós, Esther Vazquez, A.R. Kyvik, Judith Guasch, Antonio Villaverde, Jaume Veciana, Imma Ratera

ACS Applied Materials & Interfaces· Volume 10· Issue 30
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Source abstract

Abstract

A versatile evaporation-assisted methodology based on the coffee-drop effect is described to deposit nanoparticles on surfaces, obtaining for the first time patterned gradients of protein nanoparticles (pNPs) by using a simple custom-made device. Fully controllable patterns with specific periodicities consisting of stripes with different widths and distinct nanoparticle concentration as well as gradients can be produced over large areas (∼10 cm2) in a fast (up to 10 mm2/min), reproducible, and cost-effective manner using an operational protocol optimized by an evolutionary algorithm. The developed method opens the possibility to decorate surfaces “a-la-carte” with pNPs enabling different categories of high-throughput studies on cell motility.
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Research context

NanomaterialsMaterials processing

OpenAlex topics: Nanomaterials and Printing Technologies · Microfluidic and Bio-sensing Technologies · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Molecular Nanoscience and Organic Materials, Institut de Ciència de Materials de Barcelona (CSIC), Campus UAB, 08193 Bellaterra, Spain

CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 08193 Bellaterra, Spain

Dynamic Biomaterials for Cancer Immunotherapy, Max Planck Partner Group, ICMAB-CSIC, Campus UAB, 08193 Bellaterra, Spain

Funding

Centro de Investigaci?n Biom?dica en Red en Bioingenier?a, Biomateriales y Nanomedicina · Instituto Nacional de Investigaci?n y Tecnolog?a Agraria y Alimentaria · Generalitat de Catalunya · FP7 People: Marie-Curie Actions · Consejo Superior de Investigaciones Cient?ficas · Ministerio de Ciencia e Innovaci?n · Ministerio de Econom?a y Competitividad · Fundaci?n Cient?fica Asociaci?n Espa?ola Contra el C?ncer · Max-Planck-Gesellschaft · European Cooperation in Science and Technology · European Social Fund · Horizon 2020 Framework Programme · Instituci? Catalana de Recerca i Estudis Avan?ats

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