Controlled Interfacial Permeation, Nanostructure Formation, Catalytic Efficiency, Signal Enhancement Capability, and Cell Spreading by Adjusting Photochemical Cross-Linking Degrees of Layer-by-Layer Films

Interfacial properties including permeation, catalytic efficiency, Raman signal enhancement capabilities, and cell spreading efficiencies are important features that determine material functionality and applications. Here, we propose a facile method to adjust the above-mentioned properties by controlling the cross-linking degrees of multilayer using a photoactive molecule. After treating the cross-linked films in basic solutions, films with different cross-linking degrees presented varying residue thicknesses and film morphologies. As a result, these different films possessed distinct molecular loading and release characteristics. In addition, gold nanoparticles (AuNPs) of different morphological traits were generated by redox reactions coupled with diffusion within these films. The AuNP-polyelectrolyte obtained from the polyelectrolyte films of the medium cross-linking degrees displayed the highest catalytic efficiency and signal enhancement capabilities. Furthermore, cells responded to the variation of film cross-linking degrees, and on the films with the highest cross-linking degree, cells adhered with the highest speed. We expect this report to provide a general interfacial material engineering strategy for material designs.