DataVXACS Applied Materials & InterfacesPaper
journal article·2022-03-02

Design and Realization of Triple dsDNA Nanocomputing Circuits in Microfluidic Chips

Songlin He, Ruiming Cui, Yao Zhang, Yongkang Yang, Ziheng Xu, Shuoyu Wang, Pingxiu Dang, Kexin Dang, Qing Ye, Yin Liu

ACS Applied Materials & Interfaces· Volume 14· Issue 8
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Source abstract

Abstract

DNA logic gates, nanocomputing circuits, have already implemented basic computations and shown great signal potential for nano logic material application. However, the reaction temperature and computing speed still limit its development. Performing complicated computations requires a more stable component and a better computing platform. We proposed a more stable design of logic gates based on a triple, double-stranded, DNA (T-dsDNA) structure. We demonstrated a half adder and a full adder using these DNA nanocircuits and performed the computations in a microfluidic chip device at room temperature. When the solutions were mixed in the device, we obtained the expected results in real time, which suggested that the T-dsDNA combined microfluidic chip provides a concise strategy for large DNA nanocircuits.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanopore and Nanochannel Transport Studies · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Medicine, Nankai University, Tianjin 300071, People’s Republic of China

Institute of Orthopedics, the First Medical Center, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA; No. 28 Fuxing Road, Haidian District, Beijing 100853, People’s Republic of China

Key Laboratory of Weak-Light Nonlinear Photonics, Ministry of Education, School of Physics and TEDA Applied Physics, Nankai University, Tianjin 300071, People’s Republic of China

Nankai University Eye Institute, Nankai University, Tianjin 300071, People’s Republic of China

Funding

National Undergraduate Training Program for Innovation and Entrepreneurship

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