Omniphilic Polysaccharide-Based Nanocarriers for Modular Molecular Delivery in a Broad Range of Biosystems
Source abstract
Abstract
Self-adjusting omniphilic nanocarriers (OPNs) with a multisolvent aptitude were prepared via a Schiff base reaction between chitosan, a natural polysaccharide, and bioactive aldehydes. Experimental studies supported by atomistic molecular dynamics simulations revealed these OPNs can encapsulate insoluble molecular cargo, transport them in aqueous or lipid environments, and deliver them through cross-phase barriers. N-imine dynamic covalent bonds have been incorporated to endow the OPNs with pH responsiveness, also allowing the amplification of their bioactivity, as demonstrated in vitro with the ability to delay fungal proliferation in wheat grains. The reported OPNs hold remarkable potential as biocompatible nanocarriers for the effective delivery of active agents in agriculture, medicine, and cosmetics.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanocomposite Films for Food Packaging · Pickering emulsions and particle stabilization · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Postharvest and Food Science Institute, Agricultural Research Organization, The Volcani Center, Rishon LeZion 50250, Israel
Department of Chemistry, University of Illinois at Chicago, Chicago 60607, Illinois, United States
The Center for Nanoscience and Nanotechnology, and the Silberman Institute for Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
The Skin Research Institute, Dead Sea & Arava Science Center, Masada 86910, Israel
Departments of Physics and Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago 60607, Illinois, United States
Funding
Division of Materials Research · Chief Scientist of the Israeli Ministry of Agriculture · Agricultural Research Organization, Volcani Center
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