DataVXACS Applied Materials & InterfacesPaper
journal article·2015-04-08

Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association

Fen Wu, Juan Jin, Liying Wang, Pengfei Sun, Huanxiang Yuan, Zhongqiang Yang, Guosong Chen, Qing-Hua Fan, Dongsheng Liu

ACS Applied Materials & Interfaces· Volume 7· Issue 13
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Source abstract

Abstract

Specific carbohydrate recognition in biology is a dynamic process. Thus, supramolecular multivalent scaffolds with dynamic features have been applied to mimic this process. Herein, we prepared DNA-dendron supramolecular fibers and synthesized carbohydrate-oligonucleotide conjugates (C18-mannose). Via DNA hybridization, the C18-mannose could be guided onto the fiber platform and form multiple mannose-functionalized fibers, which can be utilized to agglutinate E. coli because of high affinity among multivalent mannose ligands and receptors on E. coli. In addition, via chain exchange reaction of DNAs, the E. coli could be dissociated by replacing multivalent mannose ligands with competitive unmodified DNA sequences. The association and dissociation processes of E. coli are confirmed by fluorescent microscope and transmission electron microscope (TEM). These results not only demonstrate the ability of DNA-dendron fibers in reversibly associating E. coli but also illustrate their potential to be an easily modified multivalent supramolecular platform.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China

Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China

Funding

Ministry of Science and Technology of the People's Republic of China · Deutsche Forschungsgemeinschaft · National Natural Science Foundation of China · Science and Technology Commission Beijing Municipality

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