Computational Nanomechanics of Noncollagenous Interfibrillar Interface in Bone
Source abstract
Abstract
The noncollagenous interfibrillar interface in bone provides the critical function of transferring loads among collagen fibrils and their bundles, with adhesive mechanisms at this site thus significantly contributing to the mechanical properties of bone. Motivated by the experimental observations and hypotheses, a computational study is presented to elucidate the critical roles of two major proteins at the nanoscale interfibrillar interface, that is, osteopontin (OPN) and osteocalcin (OC) in bone. This study reveals the extremely high interfacial toughness of the OPN/OC composite. The previously proposed hypothesis of sacrificial bonds in the extracellular organic matrix is tested, and the remarkable mechanical properties of the nanoscale bone interface are attributed to the collaborative interactions between the OPN and OC proteins.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone and Dental Protein Studies · Bone health and osteoporosis research · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical Engineering, The University of Texas at Dallas, 800 West Campbell Road, Richardson, Texas 75080, United States
College of Material and Textile Engineering, Jiaxing University, Jiaxing 314001, People’s Republic of China
Funding
Division of Civil, Mechanical and Manufacturing Innovation · National Natural Science Foundation of China
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