Topographical Binding to Mucosa-Exposed Cancer Cells: Pollen-Mimetic Porous Microspheres with Tunable Pore Sizes
Source abstract
Abstract
Mucoadhesives have been perceived as an effective approach for targeting the mucosa-associated diseases, which relied on the adhesive molecules to enhance the specificity. Here, topographical binding is proposed based on the fabrication of surface pore size tunable pollen-mimetic microspheres with phase separation and electrospray technology. We proved that microspheres with large-pores (pore size of 1005 ± 448 nm) were the excellent potential candidate for the mucoadhesives, as they not only possessed better adhesion ability, but also could topographically bind cervical cancer cells. Our methods of topographical binding offered a new way of designing the mucoadhesives for treating the mucosa-associated diseases.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Pickering emulsions and particle stabilization · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
National Center for Nanoscience and Technology, Beijing 100190, China
Engineering Research Center of Marine Biological Resource Comprehensive Utilization, The Third Institute of Oceanography of the State Oceanic Administration, Xiamen 361005, China
Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
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