Gradient and Patterned Protein Films Stabilized via Nanoimprint Lithography for Engineered Interactions with Cells

Li-Sheng Wang; Bradley Duncan; Rui Tang; Yi-Wei Lee; Brian Creran; Sukru Gokhan Elci; Jiaxin Zhu; Gülen Yesilbag Tonga; Jesse Doble; Matthew Fessenden; Mahin Bayat; Stephen Nonnenmann; Richard W. Vachet; Vincent M. Rotello

doi:10.1021/acsami.6b13815

journal article·2017-01-11

Gradient and Patterned Protein Films Stabilized via Nanoimprint Lithography for Engineered Interactions with Cells

Li-Sheng Wang, Bradley Duncan, Rui Tang, Yi-Wei Lee, Brian Creran, Sukru Gokhan Elci, Jiaxin Zhu, Gülen Yesilbag Tonga, Jesse Doble, Matthew Fessenden, Mahin Bayat, Stephen Nonnenmann, Richard W. Vachet, Vincent M. Rotello

ACS Applied Materials & Interfaces· Volume 9· Issue 1

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Source abstract

Abstract

Protein-based biomaterials provide versatile scaffolds for generating functional surfaces for biomedical applications. However, tailoring the functional and biological properties of protein films remains a challenge. Here, we describe a high-throughput method to designing stable, functional biomaterials by combining inkjet deposition of protein inks with a nanoimprint lithography based methodology. The translation of the intrinsically charged proteins into functional materials properties was demonstrated through controlled cellular adhesion. This modular strategy offers a rapid method to produce customizable biomaterials.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials Materials processing

OpenAlex topics: Nanofabrication and Lithography Techniques · 3D Printing in Biomedical Research · Silk-based biomaterials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Massachusetts—Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States

Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States

Funding

Division of Chemistry · Division of Civil, Mechanical and Manufacturing Innovation

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