DataVXACS Applied Materials & InterfacesPaper
journal article·2026-01-21

Macrocyclic Pyclen-Based Hybrid Nanoprobes for Magnetic Resonance Imaging of Sentinel Lymph Node Metastasis

Haojie Gu, Yuting Jiang, Zhongyuan Cai, Shengxiang Fu, Yingzi Cao, Xiaomin Fu, Na Li, Li Liu, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai

ACS Applied Materials & Interfaces· Volume 18· Issue 2
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Source abstract

Abstract

The clinical diagnosis of sentinel lymph node (SLN) metastasis through contrast-enhanced magnetic resonance imaging (MRI) remains challenging. In this work, a pyclen-based amphiphilic gadolinium chelate (GdL) was developed and coassembled with DSPE-PEG2000 to form hybrid micelles for SLN metastasis imaging. The micelles exhibited high relaxivity and kinetic stability, with particle size and relaxivity adjustable by modifying the DSPE-PEG/GdL mass ratio. The DSPE-PEG/GdL micelles (15:1) displayed the highest T 1 relaxivity (23.5 Gd mM –1 s –1 at 1.5 T), which is 5.6-fold greater than that of Gd-DOTA, coupled with high kinetic stability. In a mouse model of breast cancer lymph node metastasis, SLN was successfully distinguished at a much lower dosage (0.75 or 1.5 mg Gd kg –1 BW) compared to the clinical dose of 15.7 mg Gd kg –1 BW, as evidenced by differences in MR signal intensity. Overall, the strategy of coassembling pyclen-based Gd chelates with DSPE-PEG2000 offers a feasible approach for developing effective MR probes for lymph node metastasis imaging.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Engineering Research Center for Biomaterials

Sichuan University

College of Biomedical Engineering

Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital

Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital

Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital

Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital

State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital

Department of Radiology, West China Hospital

Funding

West China Hospital, Sichuan University · National Major Science and Technology Projects of China · Natural Science Foundation of Sichuan Province · National Natural Science Foundation of China

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