DataVXACS Applied Materials & InterfacesPaper
journal article·2025-10-29

Helical Pitch Regulates Fatigue Resistance of Fiber-Reinforced Hydrogel

Xu Zhang, Wenxu Sun, Yi Cao, Bin Xue, Leping Li, Chunping Jiang, Junsheng Zhang

ACS Applied Materials & Interfaces· Volume 17· Issue 43
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Source abstract

Abstract

Hydrogels are emerging as promising soft platforms for tissue engineering, flexible sensors, and soft robotics. Hydrogels that incorporate hierarchical fiber structures exhibit significantly enhanced mechanical stability and durability. However, the influence of nanostructural fiber characteristics on the mechanical properties of hydrogels, particularly when these fibers form hierarchical architectures, remains poorly understood. In this study, we designed hydrogels by integrating a series of fibers with varying helical pitches assembled from short amphiphilic peptides. The helical pitch of these fibers regulates the dissipation of mechanical loads at different rates, endowing the hydrogels with diverse fatigue resistance. We demonstrate that the helical pitch of the fiber plays a crucial role in regulating energy dissipation of the hydrogels, directly influencing their mechanical stability and fatigue resistance. Our findings highlight the critical role of fiber helical pitch in mechanical energy dissipation and provide molecular-level insights into tailoring hydrogel network structures to enhance mechanical performance.
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Research context

PolymersNanomaterialsBiomaterialsComposites

OpenAlex topics: Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications · Polymer-Based Agricultural Enhancements

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shandong First Medical University & Shandong Academy of Medical Sciences

Jinan Microecological Biomedicine Shandong Laboratory

Department of Gastrointestinal Surgery

Shandong Provincial Hospital Affiliated to Shandong First Medical University

School of Physical Science and Technology

Nantong University

Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid-State Microstructure, Department of Physics

Nanjing University

Medical Science and Technology Innovation Center

Key Laboratory of Engineering of Shandong Province

Shandong Provincial Hospital

Department of Gastrointestinal Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine

Shandong University

Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School

Department of Hepatobiliary and Pancreatic Surgery

The Second Affiliated Hospital of Fujian Medical University

Renhuai People’s Hospital

State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering

Ningxia University

Funding

National Key Research and Development Program of China · Natural Science Foundation of Jiangsu Province · Natural Science Foundation of Ningxia Province · National Natural Science Foundation of China · Research Project of Jinan Microecological Biomedicine Shandong Laboratory · Shandong Provincial Laboratory Project · Yinchuan Young Scientific and Technological Talent Cultivation Project

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