DataVXACS Applied Materials & InterfacesPaper
journal article·2025-09-10Open access

Bioorthogonal Mussel-Inspired Elastin-like Nanocoatings for Indwelling Devices

Sergio Acosta, Viktoriya Chaskovska, Ikram El-Maachi, Jenny Englert, María Puertas-Bartolomé, Stefan Jockenhoevel, José Carlos Rodríguez-Cabello, César Rodriguez-Emmenegger, Alicia Fernández-Colino

ACS Applied Materials & Interfaces· Volume 17· Issue 36
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Source abstract

Abstract

Medical devices such as vascular grafts, stents, and catheters are crucial for patient treatment but often suffer suboptimal integration with host tissues due to the nature of their surfaces. The materials commonly used, including metals and synthetic polymers, frequently lead to undesired immune responses and device failure. In this context, coating their surfaces with designer proteins has arisen as a promising strategy to improve the device's biointegration. Here, we present a bioinspired method for coating biomaterial surfaces with protein-engineered polymers designed to mimic tailored functions from the native extracellular matrix (ECM). Combining mussel-inspired catechol chemistry with bioorthogonal click chemistry, we developed a modular grafting method for the surface functionalization of metallic and polymeric implants using a bifunctional peptide containing azide and DOPA (3,4-dihydroxyphenylalanine) groups. This simple dip-coating process enabled the fabrication of bioactive elastin-like coatings with precise peptide presentation. The results reveal enhanced bioactivity and cytocompatibility, as evidenced by improved endothelial cell adhesion, proliferation, and heparin-binding capacity on coated surfaces. The versatility and effectiveness of this bioorthogonal coating method suggest significant potential for creating implant surfaces tailored to diverse clinical applications.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Silk-based biomaterials and applications · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biohybrid & Medical Textiles (BioTex), AME − Institute of Applied Medical Engineering, Helmholtz Institute

RWTH Aachen University

Bioforge Laboratory (Group for Advanced Materials and Nanobiotechnology), Laboratory for Disruptive Interdisciplinary Science (LaDIS), CIBER-BBN, Edificio LUCIA

Universidad de Valladolid

DWI Leibniz Institute for Interactive Materials, Forckenbeckstraße 50, 52074 Aachen, Germany

Chair of Biotechnology

Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Carrer de Baldiri Reixac 10-12, 08028 Barcelona, Spain

Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, 08010 Barcelona, Spain

Biomedical Research Networking, Center in Bioengineering, Biomaterials and Nanomedicine

The Institute of Health Carlos III

Funding

Bundesministerium f?r Bildung und Forschung · Centro de Investigaci?n Biom?dica en Red en Bioingenier?a, Biomateriales y Nanomedicina · Consejer?a de Educaci?n, Junta de Castilla y Le?n · European Regional Development Fund · Deutsche Forschungsgemeinschaft · Institute for Bioengineering of Catalonia · Generalitat de Catalunya · HORIZON EUROPE Digital, Industry and Space

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