journal article·2025-09-10

Carrier-free Nano-Tetrandrine (PURE-T) for Psoriasis Treatment: Significant Therapeutic Efficacy and Its Regulatory Mechanism on Stratum Corneum Inflammation

Liang Zhang, Bocheng Yang, Ziqi Zhuang, Yating Zheng, Yi Xue, Yao Cheng, Liqian Zhao, Lili Jiang, Changhong Li, Jinyong Lin, Anqi Wang, Wei Zhou, Chengchao Chu, Peiyu Wang, Gang Liu, Xiaofei Wen, Yan You

ACS Applied Materials & Interfaces· Volume 17· Issue 36
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Abstract

As an incurable systemic autoimmune disease, psoriasis is in urgent need of safe and effective treatment strategies. As a natural product extracted from Chinese herbs, Tetrandrine (Tet) has a wide range of pharmacological effects. In this study, we developed a carrier-free nano Tet topical formulation (PURE-T) by antisolvent method, and verified that it could selectively attenuate the toxicity of HaCaT cells in the normal state and potentiate the efficacy of HaCaT cells in the inflammatory state in vitro, and in vivo experiments verified that it could normalize the epidermal layer of the skin of imiquimod (IMQ)-induced psoriasis-like mice, and reduce the infiltration of inflammatory cells in the superficial layer of the dermis; mechanistic studies suggested that PURE-T may achieve therapeutic treatment of psoriasis through the GSDMC-mediated noninflammatory pyroptosis pathway. This safe, effective, carrier-free topical nanoformulation has potential for clinical translation and large-scale production.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Psoriasis: Treatment and Pathogenesis · Inflammasome and immune disorders · Autoimmune and Inflammatory Disorders Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Dermatology, The Fourth Affiliated Hospital of Harbin Medical University, No. 37, Yiyuan Street, Nangang District, Harbin 150001, China

Department of Vascular & Tumor Interventional Radiology

The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University

Division of Plastic Surgery

Zhongshan Hospital Xiamen University

State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, National Innovation Platform for Industry-Education Integration in Vaccine Research, Fujian Engineering Research Center of Molecular Theranostic Technology, Center for Molecular Imaging and Translational Medicine, School of Public Health

Xiamen University

Department of Dermatology

Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health

Institute of Translational Medicine

Zhejiang University School of Medicine

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences

Quanzhou Center for Disease Control and Prevention

Department of Dermatology, Peking University Third Hospital, No. 49 Huayuan North Road, Haidian District, Beijing 100191, China

School of Chemistry and Chemical Engineering

Inner Mongolia University of Science & Technology

Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine

The Key Laboratory of Biomedical Imaging Science and System

Chinese Academy of Sciences

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Heilongjiang Provincial Science and Technology Department · Natural Science Foundation of Zhejiang Province · State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory · Xiamen Public Hospital High Quality Development Project · Young and Middle-aged Talent Training Plan of Xiamen Health High-quality Development Science and Technology Program · Xiamen Health High-Level Talent Training Program

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