An Exploration into the Safe and Precise In Vivo Fluorescence Visualization of Uteroplacental Circulation in the NIR-II Window
Source abstract
Abstract
The uteroplacental circulation is essential for maintaining normal placental physiology and ensuring fetal development. Imaging this circulation is crucial for a comprehensive understanding of its physiological characteristics and associated pathological processes. Fluorescence imaging in the second near-infrared window (NIR-II, 900-1880 nm) offers significant advantages, including high resolution and deep tissue penetration, facilitating more accurate in vivo assessments. In this study, we employed nanoparticles composed of organic fluorescent dyes with NIR-II emission for precise imaging of the uteroplacental circulation. This approach enabled visualization of the uterine artery and placental blood perfusion in pregnant mice with high resolution. We successfully examined the developmental status across different pregnancy stages and assessed pathological alterations associated with inflammation-induced injury. Furthermore, the maternal and fetal safety of the nanoparticles was validated through comprehensive evaluations. These investigations present a novel approach for studying the formation and development of uteroplacental circulation, as well as related pathological conditions.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Pregnancy and preeclampsia studies · Maternal and fetal healthcare · Climate Change and Health Impacts
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education) and Women’s Hospital
Zhejiang University School of Medicine
State Key Laboratory of Extreme Photonics and Instrumentation, International Research Center for Advanced Photonics, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering
Zhejiang University
State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology, Institute of Green Petroleum Processing and Light Hydrocarbon Conversion, College of Chemical Engineering
Zhejiang University of Technology
Key Laboratory of Safety Evaluation of Medical Devices of Zhejiang Province
Zhejiang Provincial Birth Defect Control and Prevention Research Center
Funding
National Key Research and Development Program of China · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Key Laboratory of Safety Evaluation of Medical Devices of Zhejiang Province
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