journal article·2025-01-08

Sticky Polyelectrolyte Shield for Enhancing Biological Half-Life of Growth Factors

Young Kim, Sungmi Jeon, Byulhana Kim, Yu Jin Jeong, Tae Hee Kim, Subin Jeong, Iljin Kim, Joomin Oh, Youngmee Jung, Kangwon Lee, Young Bin Choy, Sang Wha Kim, Justin J. Chung

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Abstract

Delivery of secretomes, which includes growth factors, cytokines, and mRNA, is critical in regenerative medicine for cell-to-cell communication. However, the harsh in vivo environment presents significant challenges for secretome delivery. Proteolytic enzymes shorten secretomes’ half-lives, and secretomes tend to rapidly diffuse at defect sites. Therefore, a delivery system that ensures prolonged retention and enhanced therapeutic efficacy of secretomes is required. In this study, a Coating Optimized Drug Delivery Enhancement (COD 2 E) system, a coacervate composed of dopamine functionalized fucoidan and poly- l -lysine, was fabricated for secretome delivery. The dopamine modification significantly enhanced adhesive strength (>7-fold) compared to that of the neat coacervates, which enabled rapid (5 min) and uniform coating ability on collagen sponges. The COD 2 E system was able to encapsulate fibroblast growth factor (FGF2) and prolong the half-life of FGF2. Notably, its efficacy, demonstrated through a single application of FGF2 encapsulated COD 2 E on collagen sponge, in a wound model demonstrated a successful tissue repair. The COD 2 E system is an effective growth factor delivery vehicle since it can protect growth factors, has an antioxidant ability, adheres on various material surfaces, and is hemocompatible.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea

Innovative Medical Technology Research Institute, Seoul National University Hospital, Seoul 03080, Republic of Korea

Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Department of Clinical Medical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Division of Pediatric Plastic Surgery, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Department of Plastic and Reconstructive Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Interdisciplinary Program in Bioengineering College of Engineering, Seoul National University, Seoul 08826, Republic of Korea

Department of Fusion Research and Collaboration, Biomedical Research Institute, Seoul National University, Seoul 03080, Republic of Korea

Department of Pharmacology and Program in Biomedical Science and Engineering, Inha University College of Medicine, Incheon 22212, South Korea

Biomaterials Research Center, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

School of Electrical and Electronic Engineering, YU-KIST, Yonsei University, Seoul 03722, Republic of Korea

Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea

Research Institute for Convergence Science, Seoul National University, Seoul 08826, Republic of Korea

Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea

Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

Funding

Ministry of Science and ICT, South Korea · Seoul National University Hospital · Naver Corporation

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