Synergistic ROS Generation via Core–Shell Nanostructures with Increased Lattice Microstrain Combined with Single-Atom Catalysis for Enhanced Tumor Suppression

High Resolution Image Download MS PowerPoint Slide This study emphasizes the innovative application of FePt and Cu core–shell nanostructures with increased lattice microstrain, coupled with Au single-atom catalysis, in significantly enhancing • OH generation for catalytic tumor therapy. The combination of core–shell with increased lattice microstrain and single-atom structures introduces an unexpected boost in hydroxyl radical ( • OH) production, representing a pivotal advancement in strategies for enhancing reactive oxygen species. The creation of a core–shell structure, FePt@Cu, showcases a synergistic effect in • OH generation that surpasses the combined effects of FePt and Cu individually. Incorporating atomic Au with FePt@Cu/Au further enhances • OH production. Both FePt@Cu and FePt@Cu/Au structures boost the O 2 → H 2 O 2 → • OH reaction pathway and catalyze Fenton-like reactions. This enhancement is underpinned by DFT theoretical calculations revealing a reduced O 2 adsorption energy and energy barrier, facilitated by lattice mismatch and the unique catalytic activity of single-atom Au. Notably, the FePt@Cu/Au structure demonstrates remarkable efficacy in tumor suppression and exhibits biodegradable properties, allowing for rapid excretion from the body. This dual attribute underscores its potential as a highly effective and safe cancer therapeutic agent.