Block Co-PolyMOC Micelles and Structural Synergy as Composite Nanocarriers
Source abstract
Abstract
Conventional micelles of amphiphilic block copolymers (BCPs) disassemble into individual polymer chains upon dilution to a critical concentration, which causes the premature release of the encapsulated drugs and reduces the drug’s bioavailability. Here, by integrating the emerging metal–organic cage (MOC) materials with BCPs, we introduce a new type of composite micellar nanoparticles, block co-polyMOC micelles (or BCPMMs), that are self-assembled in essence yet remarkably stable against dilution. BCPMMs are fabricated via a stepwise assembly strategy that combines MOCs and BCPs in a well-defined, unimolecular core–shell structure. The synergistical interplay between the two components accounts for the particle stability: the MOC core holds BCPs firmly in place and the BCPs increase the MOC’s bioavailability. When used as nanocarriers for anticancer drugs, BCPMMs showed an extended blood circulation, a favorable biodistribution, and eventually an improved treatment efficacy in vivo. Given the versatility in designing MOCs and BCPs, we envision that BCPMMs can serve as a modular platform for robust, multifunctional, and tunable nanomedicine.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Dendrimers and Hyperbranched Polymers · Advanced Polymer Synthesis and Characterization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR 999077, China
Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Qingdao Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266071, China
Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 999077, China
Laboratory of Molecular Engineering and Nanomedicine, Dr. Li Dak-Sum Research Centre, The University of Hong Kong, Hong Kong SAR 999077, China
Funding
Research Grants Council, University Grants Committee · University of Hong Kong · Shanghai Municipal Education Commission · National Natural Science Foundation of China · Recruitment Program of Global Experts · Innovative Research Team of High-level Local Universities in Shanghai
References (70)
Show source-provided references
1. 10.1146/annurev-med-040210-16254410.1146/annurev-med-040210-162544 ↗
2. 10.1038/nbt.333010.1038/nbt.3330 ↗
3. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗
4. 10.1016/j.progpolymsci.2005.04.00210.1016/j.progpolymsci.2005.04.002 ↗
5. 10.1016/j.addr.2012.09.01310.1016/j.addr.2012.09.013 ↗
6. 10.1039/C3RA47370H10.1039/C3RA47370H ↗
7. 10.1517/1742524090338044610.1517/17425240903380446 ↗
8. 10.1021/ar900035f10.1021/ar900035f ↗
9. 10.1021/la053199810.1021/la0531998 ↗
10. 10.1016/j.jconrel.2011.12.01210.1016/j.jconrel.2011.12.012 ↗
11. 10.1016/j.canlet.2012.07.00610.1016/j.canlet.2012.07.006 ↗
12. 10.1073/pnas.070704610510.1073/pnas.0707046105 ↗
13. 10.1007/s12274-018-2152-310.1007/s12274-018-2152-3 ↗
14. 10.1039/C6PY01006G10.1039/C6PY01006G ↗
15. 10.1016/j.addr.2018.07.00810.1016/j.addr.2018.07.008 ↗
16. 10.1016/j.addr.2013.09.00810.1016/j.addr.2013.09.008 ↗
17. 10.1021/bc000058310.1021/bc0000583 ↗
18. 10.1039/c0sm00999g10.1039/c0sm00999g ↗
19. 10.1016/j.nano.2010.05.00510.1016/j.nano.2010.05.005 ↗
20. 10.1016/j.cossms.2012.10.00310.1016/j.cossms.2012.10.003 ↗
21. 10.1039/C1CS15242D10.1039/C1CS15242D ↗
22. 10.1039/C2SM26509E10.1039/C2SM26509E ↗
23. 10.1016/j.polymer.2011.04.05410.1016/j.polymer.2011.04.054 ↗
24. 10.1021/cr500632f10.1021/cr500632f ↗
25. 10.1016/S1367-5931(02)00358-710.1016/S1367-5931(02)00358-7 ↗
26. 10.1039/B616752G10.1039/B616752G ↗
27. 10.1039/C2NJ40555E10.1039/C2NJ40555E ↗
28. 10.1021/cr500566610.1021/cr5005666 ↗
29. 10.1002/1521-3773(20010601)40:11<2022::AID-ANIE2022>3.0.CO;2-D10.1002/1521-3773(20010601)40:11<2022::AID-ANIE2022>3.0.CO;2-D ↗
30. 10.1126/science.118860510.1126/science.1188605 ↗
31. 10.1007/s13233-018-6156-310.1007/s13233-018-6156-3 ↗
32. 10.1016/j.ccr.2015.05.01610.1016/j.ccr.2015.05.016 ↗
33. 10.1039/C4CS00222A10.1039/C4CS00222A ↗
34. 10.1038/s41570-019-0085-310.1038/s41570-019-0085-3 ↗
35. 10.1073/pnas.141871211110.1073/pnas.1418712111 ↗
36. 10.1021/jacs.9b0622210.1021/jacs.9b06222 ↗
37. 10.1021/cr400431410.1021/cr4004314 ↗
38. 10.1021/acs.chemrev.5b0059710.1021/acs.chemrev.5b00597 ↗
39. 10.1002/adma.20100301210.1002/adma.201003012 ↗
40. 10.1021/jacs.6b0950410.1021/jacs.6b09504 ↗
41. 10.1002/adma.20180677410.1002/adma.201806774 ↗
42. 10.1021/ja900676f10.1021/ja900676f ↗
43. 10.1021/jacs.5b0550710.1021/jacs.5b05507 ↗
44. 10.1021/jacs.7b0730310.1021/jacs.7b07303 ↗
45. 10.1038/nchem.239010.1038/nchem.2390 ↗
46. 10.1038/s41586-018-0339-010.1038/s41586-018-0339-0 ↗
47. 10.1021/jacs.6b0671210.1021/jacs.6b06712 ↗
48. 10.1021/jacs.7b0922410.1021/jacs.7b09224 ↗
49. 10.1021/acs.chemmater.0c0061510.1021/acs.chemmater.0c00615 ↗
50. 10.1021/jacs.6b0671210.1021/jacs.6b06712 ↗
51. 10.2217/17435889.2.5.66910.2217/17435889.2.5.669 ↗
52. 10.1016/j.biomaterials.2011.02.04410.1016/j.biomaterials.2011.02.044 ↗
53. 10.1039/c2cs35115c10.1039/c2cs35115c ↗
54. 10.3390/polym811039710.3390/polym8110397 ↗
55. 10.3390/pharmaceutics1004020910.3390/pharmaceutics10040209 ↗
56. 10.1016/j.ccr.2020.21318110.1016/j.ccr.2020.213181 ↗
57. 10.1039/C5DT01259G10.1039/C5DT01259G ↗
58. 10.1002/asia.20150123810.1002/asia.201501238 ↗
59. 10.1093/chromsci/bmr03910.1093/chromsci/bmr039 ↗
60. 10.1016/j.nantod.2012.01.00210.1016/j.nantod.2012.01.002 ↗
61. 10.1016/j.biomaterials.2011.01.02110.1016/j.biomaterials.2011.01.021 ↗
62. 10.1146/annurev-bioeng-071811-15012410.1146/annurev-bioeng-071811-150124 ↗
63. 10.1038/s41551-018-0234-x10.1038/s41551-018-0234-x ↗
64. 10.1073/pnas.191365511710.1073/pnas.1913655117 ↗
65. 10.1039/C2SC00899H10.1039/C2SC00899H ↗
66. 10.1002/anie.20080170010.1002/anie.200801700 ↗
67. 10.1016/j.biomaterials.2013.01.08410.1016/j.biomaterials.2013.01.084 ↗
68. 10.1126/science.aad308710.1126/science.aad3087 ↗
69. 10.1021/ja910484210.1021/ja9104842 ↗
70. 10.1126/science.aad827910.1126/science.aad8279 ↗