journal article·2025-02-12

Cystine-Modified Lignin–Copper Coordination Nanocarriers Improve the Therapeutic Efficacy of Tyrosine Kinase Inhibition via Cuproptosis

Shiyao Song, Xingfeng Qiu, Shaoqing Huang, Huixuan Tian, Ruihan Pu, Jingyi Huang, Jiayin Su, Yan-Lai Tang, Libin Huang, Xuequn Luo, Weiling He, Qingfeng Ni, Weijing Zhang

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Abstract

The clinical application of tyrosine kinase inhibitors (TKIs) is rapidly growing and has emerged as a cornerstone in the treatment of both solid tumors and hematologic malignancies. However, resistance to TKI targets and disease progression remain inevitable. Nanocarrier-mediated delivery has emerged as a promising strategy to overcome the limitations of the TKI application. We utilized the facile modification of lignin polyhydroxyl groups to synthesize cystine-grafted lignin–copper coordinated nanoparticles for TKI delivery via the Mannich reaction. The materials exhibited a stable, uniform morphology and effectively encapsulated and delivered a variety of TKI inhibitors. Moreover, we optimized the fabrication process and found that the material could release the encapsulated drug in response to both pH and GSH. These nanoparticles significantly enhanced the therapeutic activity of TKIs both in vitro and in vivo through cuproptosis while demonstrating good biosafety. We propose a novel strategy for the targeted delivery of TKI inhibitors by combining cuproptosis with modified lignin. This approach not only offers new strategies for the clinical application of TKIs but also provides novel insights and inspiration for the modified use of lignin.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Lignin and Wood Chemistry · Enzyme-mediated dye degradation · Synthesis of Organic Compounds

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pediatrics

The First Affiliated Hospital, Sun Yat-sen University

Department of Gastrointestinal Surgery

Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University

School of Public Health

Sun Yat-sen University

The University of Hongkong-Shenzhen Hospital

Affiliated Hospital of Nantong University

Department of Radiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, No. 651 Dongfeng Road East, Guangzhou, Guangdong 510060, P. R. China

Funding

National Key Research and Development Program of China · Basic and Applied Basic Research Foundation of Guangdong Province · Natural Science Foundation of Fujian Province · National Natural Science Foundation of China · Guangdong Provincial Key Areas Research and Development Programs of ?Precision medicine and stem cells? · Natural Science Foundation for Outstanding Youth Team Project of Guangdong Province

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