DataVXACS Applied Materials & InterfacesPaper
journal article·2024-07-17Open access

Light-Induced Transformation of Virus-Like Particles on TiO2

Mona Kohantorabi, Aldo Ugolotti, Benedikt Sochor, Johannes Roessler, Michael Wagstaffe, Alexander Meinhardt, E. Erik Beck, Daniel Silvan Dolling, Miguel Blanco Garcia, Marcus Creutzburg, Thomas F. Keller, Matthias Schwartzkopf, Sarathlal Koyiloth Vayalil, Roland Thuenauer, Gabriela Guédez, Christian Löw, Gregor Ebert, Ulrike Protzer, Wolfgang Hammerschmidt, Reinhard Zeidler, Stephan V. Roth, Cristiana Di Valentin, Andreas Stierle, Heshmat Noei

ACS Applied Materials & Interfaces· Volume 16· Issue 28
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Abstract

High Resolution Image Download MS PowerPoint Slide Titanium dioxide (TiO 2 ) shows significant potential as a self-cleaning material to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and prevent virus transmission. This study provides insights into the impact of UV-A light on the photocatalytic inactivation of adsorbed SARS-CoV-2 virus-like particles (VLPs) on a TiO 2 surface at the molecular and atomic levels. X-ray photoelectron spectroscopy, combined with density functional theory calculations, reveals that spike proteins can adsorb on TiO 2 predominantly via their amine and amide functional groups in their amino acids blocks. We employ atomic force microscopy and grazing-incidence small-angle X-ray scattering (GISAXS) to investigate the molecular-scale morphological changes during the inactivation of VLPs on TiO 2 under light irradiation. Notably, in situ measurements reveal photoinduced morphological changes of VLPs, resulting in increased particle diameters. These results suggest that the denaturation of structural proteins induced by UV irradiation and oxidation of the virus structure through photocatalytic reactions can take place on the TiO 2 surface. The in situ GISAXS measurements under an N 2 atmosphere reveal that the virus morphology remains intact under UV light. This provides evidence that the presence of both oxygen and UV light is necessary to initiate photocatalytic reactions on the surface and subsequently inactivate the adsorbed viruses. The chemical insights into the virus inactivation process obtained in this study contribute significantly to the development of solid materials for the inactivation of enveloped viruses.
Source: openalex_inverted_index · Quality: baseline

Research context

Catalysis & surfaces

OpenAlex topics: COVID-19 impact on air quality · Biosensors and Analytical Detection · Dental Research and COVID-19

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for X-ray and Nano Science CXNS, Deutsches Elektronen-Synchrotron DESY, 22607 Hamburg, Germany

Dipartimento di Scienza dei Materiali, Università degli Studi di Milano-Bicocca, Via Cozzi 55, 20125 Milano, Italy

Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany

Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

Helmholtz Zentrum München, German Research Center for Environmental Health, 81377 Munich, Germany

German Center for Infection Research (DZIF), Partner Site Munich, 81377 Munich, Germany

University of Hamburg, Notkestraße 9-11, 22607 Hamburg, Germany

Department of Physics, University of Hamburg, Notkestraße 9-11, 22607 Hamburg, Germany

Applied Science Cluster, UPES, 248007 Dehradun, India

Technology Platform Light Microscopy (TPLM), Universität Hamburg (UHH), 22607 Hamburg, Germany

Centre for Structural Systems Biology (CSSB), 22607 Hamburg, Germany

Technology Platform Light Microscopy and Image Analysis (TP MIA), Leibniz Institute of Virology (LIV), 20251 Hamburg, Germany

Institute of Virology, Technical University of Munich/Helmholtz Munich, 81675 Munich, Germany

Department of Otorhinolaryngology, LMU University Hospital, LMU München, 81377 Munich, Germany

KTH Royal Institute of Technology, Teknikringen 56-58, 10044 Stockholm, Sweden

The Hamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761 Hamburg, Germany

Funding

Helmholtz-Gemeinschaft

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