Control of Neuronal Survival and Development Using Conductive Diamond
Source abstract
Abstract
This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Photoreceptor and optogenetics research · Advanced Memory and Neural Computing
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Physics, The University of Melbourne, Parkville, Victoria 3010, Australia
Department of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
Department of Mechanical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
School of Engineering, The Australian National University, Canberra, Australian Capital Territory 2601, Australia
School of Engineering, STEM College, The RMIT University, Melbourne, Victoria 3000, Australia
School of Science, STEM College, The RMIT University, Melbourne, Victoria 3000, Australia
School of Engineering, The RMIT University, Melbourne, Victoria 3000, Australia
Department of Biomedical Engineering, The University of Melbourne, Melbourne, Victoria 3010, Australia
Funding
Faculty of Science, University of Melbourne · National Health and Medical Research Council · Australian College of Optometry · Australian Research Council · Cass Foundation
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