journal article·2024-12-04Open access

4T1 Cell Membrane-Coated Pdots with NIR-II Absorption and Fluorescence Properties for Targeted Phototheranostics of Breast Tumors

Jintong Guo, Ye Liu, Xiao Liang, Zhiyi Chen, Bin Liu, Zhen Yuan

ACS Applied Materials & Interfaces· Volume 16· Issue 48

Abstract

High Resolution Image Download MS PowerPoint Slide Designing highly biocompatible organic semiconducting conjugated polymer dots (Pdots) with bright fluorescence and superior absorption properties in the second near-infrared window (NIR-II: 1000–1700 nm) remains a huge challenge for tumor phototheranostics. In this study, we constructed 4T1 cell membrane-coated m -PBTQ4F Pdots (CPdots) with enhanced NIR-II photoacoustic (PA) and fluorescence (FL) imaging capability for NIR-II photothermal therapy (PTT) of breast tumors. Our findings demonstrated that CPdots could specifically target breast tumors, leading to enhanced tumor accumulation after systemic administration in living mice. In addition, CPdots can not only serve as contrast agents for NIR-II PA and FL imaging for improved breast tumor detection but also generate more cytotoxic heat to improve PTT efficacy. Therefore, this pilot study opens an option avenue for developing new NIR-II Pdots with homologous targeting capability for enhanced phototheranostics of breast tumors.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Health Sciences, University of Macau, Macau SAR 99999, China

Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR 99999, China

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China

Key Laboratory of Medical Imaging Precision Theranostics and Radiation Protection, College of Hunan Province, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan 410004, China

Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong 510280, China

Funding

Universidade de Macau · Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia · Natural Science Foundation of Guangdong Province

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