Effects of Silane Monolayers on Lysophosphatidylcholine (LysoPC) Detection by Desorption Ionization on Silicon Mass Spectrometry (DIOS-MS) in Solution and Plasma
Source abstract
Abstract
Desorption ionization on silicon mass spectrometry (DIOS-MS) enables high throughput analysis of low-molecular-weight biomolecules. However, detection of metabolite biomarkers in complex fluids such as plasma requires sample pretreatment, limiting clinical application. Here, we show that porous silicon, chemically modified using monolayers of n-propyldimethylmethoxysilane molecules, is a good candidate for fingerprinting lysophosphatidylcholine (lysoPC) in plasma, without sample pretreatment, for DIOS-MS-based diagnosis (e.g., sepsis). Results were correlated to lysoPC molecule location inside/outside the pores, determined by time-of-flight secondary ion mass spectrometry profiling, and to physicochemical properties.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Mass Spectrometry Techniques and Applications · Ion-surface interactions and analysis · Metabolomics and Mass Spectrometry Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CNRS, INSA Lyon, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Univ Lyon, Ecole Centrale de Lyon, 69134 Ecully Cedex, France
CEA, LETI, Clinatec, Univ. Grenoble Alpes, 38000 Grenoble, France
INSA Lyon, Université Claude Bernard Lyon 1, CPE Lyon, INL, UMR5270, Univ Lyon, CNRS, Ecole Centrale de Lyon, 69134 Ecully Cedex, France
CEA, LETI, Univ Grenoble Alpes, F-38000 Grenoble, France
Funding
Agence Nationale de la Recherche
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