journal article·2022-09-28Open access

Poly(cannabinoid)s: Hemp-Derived Biocompatible Thermoplastic Polyesters with Inherent Antioxidant Properties

Robert Daniels, Erick Orozco Morato, Omer A. Yassin, Jiahao Mao, Zeynep Mutlu, Mayank Jain, Joseph Valenti, Mukerrem Cakmak, Lakshmi S. Nair, Gregory A. Sotzing

ACS Applied Materials & Interfaces· Volume 14· Issue 38

Abstract

The legalization of hemp cultivation in the United States has caused the price of hemp-derived cannabinoids to decrease 10-fold within 2 years. Cannabidiol (CBD), one of many naturally occurring diols found in hemp, can be purified in high yield for low cost, making it an interesting candidate for polymer feedstock. In this study, two polyesters were synthesized from the condensation of either CBD or cannabigerol (CBG) with adipoyl chloride. Poly(CBD-Adipate) was cast into free-standing films and subjected to thermal, mechanical, and biological characterization. Poly(CBD-Adipate) films exhibited a lack of cytotoxicity toward adipose-derived stem cells while displaying an inherent antioxidant activity compared to poly(lactide) films. Additionally, this material was found to be semi-crystalline and able to be melt-processed into a plastic hemp leaf using a silicone baking mold.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cannabis and Cannabinoid Research · biodegradable polymer synthesis and properties · Natural Fiber Reinforced Composites

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States

The Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, Connecticut 06030, United States

Department of Skeletal Biology and Regeneration, University of Connecticut Health Center, Farmington, Connecticut 06030, United States

School of Materials Engineering, Purdue University, West Lafayette, Indiana 47906, United States

College of Agriculture, Health, and Natural Resources, University of Connecticut, Storrs, Connecticut 06269, United States

Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut 06030, United States

Department of Biomedical Engineering, Department of Material Science and Engineering, Institute of Material Science, University of Connecticut, Storrs, Connecticut 06269, United States

Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States

Funding

National Institute of Arthritis and Musculoskeletal and Skin Diseases

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