Tumor-Targeted Perfluorinated Micelles as Efficient Theranostic Agents Combining Positron Emission Tomography and Radiosensitization
Source abstract
Abstract
We report the synthesis of biocompatible perfluorinated micelles designed to improve radiotherapeutic efficacy in a radioresistant tumor environment. In vitro and in vivo behaviors of perfluorinated micelles were assessed at both cellular and tissular levels. The micellar platform offers key advantages as theranostic tool: (i) small size, allowing deep tissue penetration; (ii) oxygen transport to hypoxic tissues; (iii) negligible toxicity in the absence of ionizing radiation; (iv) internalization into cancer cells; (v) potent radiosensitizing effect; and (vi) excellent tumor-targeting properties, as monitored by positron emission tomography. We have demonstrated strong in vitro radiosensitizing effects of the micelle and in vivo tumor targeting, making this nanometric carrier a promising tool for the potentiation of focused radiotherapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Radiation Therapy and Dosimetry · Cancer, Hypoxia, and Metabolism
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, 91191 Gif-sur-Yvette, France
Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Service Hospitalier Frédéric Joliot, 4 place du Général Leclerc, 91401 Orsay, France
Université Paris-Saclay, CNRS,Institut des Sciences Moléculaires d’Orsay, 91401 Orsay, France
Plateforme ARN Interférence (PARI), Institut de Radiobiologie Cellulaire et Moléculaire (iRCM), Université Paris-Saclay, CEA, 92260 Fontenay-aux-Roses, France
Funding
Commissariat ? l'?nergie Atomique et aux ?nergies Alternatives
References (54)
Show source-provided references
1. 10.1002/1878-0261.1269010.1002/1878-0261.12690 ↗
2. American Cancer Society. How Radiation Therapy Is Used to Treat Cancer, 2023. https://www.cancer.org/cancer/managing-cancer/treatment-types/radiation/basics.html, accessed June, 2023.
3. 10.3389/fonc.2021.76190110.3389/fonc.2021.761901 ↗
4. 10.1038/nrc.2016.1810.1038/nrc.2016.18 ↗
5. 10.1038/s12276-021-00640-910.1038/s12276-021-00640-9 ↗
6. 10.12659/MSM.93411610.12659/MSM.934116 ↗
7. 10.1097/00000421-199808000-0000810.1097/00000421-199808000-00008 ↗
8. 10.3390/cancers1101011210.3390/cancers11010112 ↗
9. 10.3857/roj.2016.0201210.3857/roj.2016.02012 ↗
10. 10.1186/s13046-021-02000-x10.1186/s13046-021-02000-x ↗
11. 10.3390/cancers1317444410.3390/cancers13174444 ↗
12. 10.1016/j.ijrobp.2018.01.04210.1016/j.ijrobp.2018.01.042 ↗
13. 10.3390/ma1104059610.3390/ma11040596 ↗
14. 10.1039/C9SC00747D10.1039/C9SC00747D ↗
15. 10.3390/pharmaceutics1401010510.3390/pharmaceutics14010105 ↗
16. 10.1016/j.coph.2020.08.01010.1016/j.coph.2020.08.010 ↗
17. 10.1081/BIO-20004665910.1081/BIO-200046659 ↗
18. 10.1016/j.cis.2021.10240710.1016/j.cis.2021.102407 ↗
19. 10.1002/adhm.20210065610.1002/adhm.202100656 ↗
20. 10.1016/j.nano.2022.10260310.1016/j.nano.2022.102603 ↗
21. 10.1016/j.nucmedbio.2012.08.00410.1016/j.nucmedbio.2012.08.004 ↗
22. 10.1039/D0NR08200G10.1039/D0NR08200G ↗
23. 10.1021/acsabm.8b0017310.1021/acsabm.8b00173 ↗
24. 10.1016/j.jfluchem.2008.07.02410.1016/j.jfluchem.2008.07.024 ↗
25. 10.1016/j.biomaterials.2012.05.04710.1016/j.biomaterials.2012.05.047 ↗
26. 10.3389/fpubh.2021.69982210.3389/fpubh.2021.699822 ↗
27. 10.1007/s10549-012-2338-410.1007/s10549-012-2338-4 ↗
28. 10.2217/nnm-2018-017110.2217/nnm-2018-0171 ↗
29. 10.1016/j.ijrobp.2010.08.04410.1016/j.ijrobp.2010.08.044 ↗
30. 10.1088/0031-9155/59/21/643110.1088/0031-9155/59/21/6431 ↗
31. 10.1007/s12282-013-0496-910.1007/s12282-013-0496-9 ↗
32. 10.1088/0031-9155/59/9/224910.1088/0031-9155/59/9/2249 ↗
33. 10.1186/1748-717X-9-15010.1186/1748-717X-9-150 ↗
34. 10.1186/s12645-017-0028-y10.1186/s12645-017-0028-y ↗
35. 10.2147/IJN.S22416010.2147/IJN.S224160 ↗
36. 10.1186/s12645-015-0012-310.1186/s12645-015-0012-3 ↗
37. 10.1186/s12645-014-0006-610.1186/s12645-014-0006-6 ↗
38. 10.1038/s41598-022-13368-x10.1038/s41598-022-13368-x ↗
39. 10.1016/j.ctrv.2010.04.00410.1016/j.ctrv.2010.04.004 ↗
40. 10.1371/journal.pone.002437410.1371/journal.pone.0024374 ↗
41. 10.1021/acsnano.5b0132010.1021/acsnano.5b01320 ↗
42. 10.1039/C9NR08714A10.1039/C9NR08714A ↗
43. 10.1039/B207512C10.1039/B207512C ↗
44. 10.1063/1.488387610.1063/1.4883876 ↗
45. 10.1002/smll.20110021210.1002/smll.201100212 ↗
46. 10.1002/chem.20110276910.1002/chem.201102769 ↗
47. 10.1073/pnas.221488812010.1073/pnas.2214888120 ↗
48. 10.15698/cst2020.01.20810.15698/cst2020.01.208 ↗
49. 10.1242/jcs.22027710.1242/jcs.220277 ↗
50. 10.1016/j.celrep.2017.03.06410.1016/j.celrep.2017.03.064 ↗
51. 10.7150/thno.3719810.7150/thno.37198 ↗
52. 10.1039/C8BM00852C10.1039/C8BM00852C ↗
53. 10.34133/research.006110.34133/research.0061 ↗
54. 10.1016/j.nucmedbio.2009.11.01010.1016/j.nucmedbio.2009.11.010 ↗