journal article·2023-09-13

Facile Synthesis of Basic Copper Carbonate Nanosheets for Photoacoustic Imaging-Guided Tumor Apoptosis and Ferroptosis and the Extension Exploration of the Synthesis Method

Sheng Zhao, Jianxin Wang, Shi-Yu Lu, Jingjing Wang, Ziqun Chen, Yihao Sun, Ting Xu, Yanqing Liu, Liang He, Chunmei Chen, Yi Ouyang, Yixin Tan, Yan Chen, Benqing Zhou, Yang Cao, Hui Liu

ACS Applied Materials & Interfaces· Volume 15· Issue 36
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Abstract

Elimination of tumor cells using carbonate nanomaterials with tumor microenvironment-responsive capacity has been explored as an effective strategy. However, their therapeutic outcomes are always compromised by the relatively low intratumoral accumulation and limited synthesis method. Herein, a novel kind of basic copper carbonate nanosheets was designed and prepared using a green synthesis method for photoacoustic imaging-guided tumor apoptosis and ferroptosis therapy. These nanosheets were synthesized with the assistance of dopamine and ammonium bicarbonate (NH 4 HCO 3 ) and the loading of glucose oxidase (GOx). NH 4 HCO 3 could not only provide an alkaline environment for the polymerization of dopamine but also supply carbonates for the growth of nanosheets. The formed nanosheets displayed good acid and near-infrared light responsiveness. After intercellular uptake, they could be degraded to release Cu 2+ and GOx, generating hydroxyl radicals through a Cu + -mediated Fenton-like reaction, consuming glucose, up-regulating H 2 O 2 levels, and down-regulating GSH levels. Tumor elimination could be achieved by hydroxyl radical-induced apoptosis and ferroptosis. More amusingly, this synthesis method can be extended to several kinds of mono-element and multi-element carbonate nanomaterials (e.g., Fe, Mn, and Co), showing great potential for further tumor theranostics.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Southwest University, Chongqing 400715, China

Chongqing Key Laboratory of Ultrasound Molecular Imaging, Institute of Ultrasound Imaging, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China

Department of Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

College of Metallurgy and Materials Engineering, Chongqing University of Science and Technology, Chongqing 401331, China

Beijing Key Laboratory for Magnetoelectric Materials and Devices (BKL-MMD), School of Materials Science and Engineering, Peking University, Beijing 100871, China

Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, China

Funding

Chongqing University of Science and Technology · China Association for Science and Technology · Natural Science Foundation of Chongqing · Li Ka Shing Foundation · Natural Science Foundation of Guangdong Province · Senior Medical Talents Program of Chongqing for Young and Middle-aged

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