journal article·2022-08-03

Cohesion Design-Led Tough Sealants with Controllably Dissolvable Properties

Chaowei Li, Wanglin Duan, Ye Zhu, Guanying Li, Min Gao, Zuquan Weng, Yuan Zhu, Yazhong Bu

ACS Applied Materials & Interfaces· Volume 14· Issue 30
Publisher page

Abstract

Leakage is a common complication of surgeries and injuries, causing pain and increasing the economic burden on patients. Although there are commercially available sealants for leakage prevention, few of them are entirely satisfactory due to disease transmission, high cost, and poor biocompatibility. In addition, none of them can be controllably removed for further healthcare. In this paper, by using cohesion design, a sealant based on amino-modified gelatin (AG) and bi-polyethylene glycol N-hydroxysuccinimide active ester (Bi-PEG-SS) was fabricated. To increase the bursting pressure, the cohesion strength was enhanced by increasing the cross-linking density of the sealant. To endow the sealant with controllably dissolvable properties, the smart succinic ester units were introduced into the cohesion network. Both the in vitro and in vivo experiments showed that this sealant processed high bursting pressure with efficient hemorrhage control. Moreover, no side effects were observed after 7 days of in vivo sealing, including little inflammation and fibrogenesis. These results, together with the easy availability of the raw materials, revealed that this sealant might be a promising alternative for leakage sealing.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Hemostasis and retained surgical items · Surgical Sutures and Adhesives · biodegradable polymer synthesis and properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108, China

Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China

Key Laboratory of Environment and Genes Related to Diseases (Xi’an Jiaotong University), Ministry of Education of China, Xi’an 710061, China

Institute of Molecular and Translational Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China

Department of Gynecology, The Affiliated Maternal and Child Healthcare Hospital of Nanchang University, Nanchang, Jiangxi 330006, China

Department of Gynecology, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, China

Funding

Key Research and Development Program of Jiangxi Province · National Natural Science Foundation of China · Natural Science Foundation of Jiangxi Province

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