DataVXACS Applied Materials & InterfacesPaper
journal article·2022-06-15

Fabrication of Redox-Controllable Bioinspired Nanochannels for Precisely Regulating Protein Transport

Le Tu, Sheng Qiu, Yuntao Li, Xiaoya Chen, Yunfeng Han, Junrong Li, Xiaoxing Xiong, Yao Sun, Haibing Li

ACS Applied Materials & Interfaces· Volume 14· Issue 23
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Source abstract

Abstract

Redox regulation is an inherent feature of nature and plays a crucial role in the transport of ions/small molecules. However, whether redox status affects the biomolecule transport remains largely unknown. To explore the effects of redox status on biomolecule transport, herein, we constructed a glutathione/glutathione disulfide (GSH/GSSG)-driven and pillar[5]arene (P5)-modified artificial nanochannel for protein transport. The results indicate that hemoglobin (Hb) protein is selectively and effectively transported across the GSH-driven P5-modified nanochannel, which suggests that the redox status of the nanochannel could affect the process of protein transport. Therefore, this redox-driven nanochannel could provide a potential application for biomolecule detection and redox-controllable biomolecular drug release.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Advanced biosensing and bioanalysis techniques · Electrochemical Analysis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou 313099, P.R. China

Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China

Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China

Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin 541199, P. R. China

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430074, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Key Laboratory of Molecular Imaging, Hubei Province · Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University

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