DataVXACS Applied Materials & InterfacesPaper
journal article·2024-09-04

NIR-II Responsive Fe-Doped Carbon Nanoparticles for Photothermal-Enhanced Chemodynamic Synergistic Oncotherapy

Xingyu Wang, Tianwei Song, Xianli Wu, Yefeng Lin, Xinyi Shi, Junchao Qian, Rongrong Nie, Hui Wang

ACS Applied Materials & Interfaces· Volume 16· Issue 35
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Source abstract

Abstract

Phototherapy has demonstrated substantial development because in the second near-infrared (NIR-II) window it has a larger tissue penetration and fewer adverse consequences. In this work, a particular kind of NIR-II responsive Fe-doped carbon nanoparticles (FDCNs) is synthesized using a one-pot hydrothermal method for combined photothermal and chemodynamic therapy. The mesoporous nanostructure of FDCN, which has a size distribution that exceeds 225 nm, allows for effective acidification. The iron ions released from these nanoparticles can catalyze the decomposition of hydrogen peroxide (H 2 O 2 ) into hydroxyl radical (•OH) for chemodynamic therapy (CDT). In addition to their CDT utility, FDCN can effectively adsorb and transform 1064 nm light into local heat, achieving a photothermal conversion efficacy (PCE) of 36.3%. This dual functionality not only allows for the direct eradication of cancer cells through photothermal therapy (PTT) but also enhances the chemodynamic reaction, creating a synergistic effect that amplifies the therapeutic outcome. The FDCN has demonstrated remarkable anticancer activity in both cellular and animal tests without incurring major systemic toxicity. This suggests that the compound has great promise for use in clinical cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

University of Science and Technology of China, Hefei 230026, China

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China

Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China

School of Medical Imaging, Binzhou Medical University, Yantai 264003, PR China

Department of Pathology and Pathophysiology, School of Basic Medicine, Anhui Medical University, Hefei, Anhui 230031, PR China

Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu 210008, PR China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Natural Science Foundation of Anhui Province · Chinese Academy of Sciences · High Magnetic Field Laboratory of Anhui Province · Hefei Institutes of Physical Science Director?s Fund · Nanjing Department of Health

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