DataVXACS Applied Materials & InterfacesPaper
journal article·2024-04-12

A Dual Functional Bioinspired Lubricant for Osteoarthritis Treatment and Potential Prevention

Ruyu Yan, Hai Yang, Ying Liu, Yanyan Wang, Sa Liu, Renjian Xie, Li Ren

ACS Applied Materials & Interfaces
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Source abstract

Abstract

Osteoarthritis (OA), primarily characterized by the deterioration of articular cartilage, is a highly prevalent joint-disabling disease. The pathological onset and progression of OA are closely related to cartilage lubrication dysfunction and synovial inflammation. Synergistic options targeted at restorative lubrication and anti-inflammation are expected to be the most attractive candidates to treat OA and perhaps help prevent it. Herein, a bioinspired lubricant (HA/PA@Lipo) was fabricated by combining anionic hyaluronan- graft -poly(2-acrylamide-2-methylpropanesulfonic acid sodium salt) (HA/PA) with cationic liposomes (Lipo) via electrostatic interaction. HA/PA@Lipo mimicked the lubrication complex located on the outer cartilage surface and was endowed cartilage with excellent cartilage-lubricating performances. After the antioxidant gallic acid (GA) was loaded for dual functionality, HA/PA@Lipo-GA was prepared with added anti-inflammatory properties. HA/PA@Lipo-GA showed favorable biocompatibility with C28/I2 cells, inhibited the production of reactive oxygen, and regulated the expression levels of anabolic genes and proteins. The therapeutic effects of HA/PA@Lipo-GA were evaluated using a sodium iodoacetate–induced OA rat model, and the preventive effects of HA/PA@Lipo-GA were estimated in vivo . The results suggested the robust potential of HA/PA@Lipo-GA with dual functions as a candidate option for OA treatment and prevention.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Knee injuries and reconstruction techniques · Shoulder Injury and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510006, China

National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China

Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, China

Key Laboratory of Biomedical Engineering of Guangdong Province, South China University of Technology, Guangzhou 510006, China

Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases (Ministry of Education), Gannan Medical University, Ganzhou 341000, China

Jiangxi Key Laboratory of Tissue Engineering, Gannan Medical University, Ganzhou 341000, China

School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China

Innovation Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Government of Jiangxi Province · Natural Science Foundation of Jiangxi Province · Gannan Medical University · Light of Soviet Area Talent Project

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