journal article·2024-03-27

Modified ZIF-8 Nanoparticles for Targeted Metabolic Treatment of Acute Spinal Cord Injury

Sen Lin, Jingwen Cui, Xiang Li, Shurui Chen, Kai Gao, Xifan Mei

ACS Applied Materials & Interfaces· Volume 16· Issue 12
Publisher page

Abstract

The activation of proinflammatory M1-type macrophages in the injured lesion accelerates the progression of a spinal cord injury (SCI). However, adverse side effects during systemic treatments targeting M1 macrophages have limited their applications. Nanoplatforms are novel carriers of traditional Chinese medicine because of their great efficiency to deliver and accumulation in the lesion. Herein, we synthesized a modified zeolitic imidazolate framework-8 (ZIF-8) nanoplatform for internalization and accumulation in the injured spinal cord and effective administration for SCI. In vitro and in vivo experiments suggested that Prussian blue and Schisandrin B modified ZIF-8 effectively accumulated in M1 macrophages, inhibited reactive oxygen species (ROS), and polarized the macrophage from proinflammatory M1 to anti-inflammatory M2 for rapid tissue infiltration by reprogramming the metabolic macrophages phenotype. This nanoplatform achieves a synergistic therapeutic effect of immunomodulation and neuroprotection, thereby shedding new light on the application of ZIF-8, and provides great potential for SCI.
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Research context

OpenAlex topics: Spinal Cord Injury Research · Spinal Dysraphism and Malformations · Spinal Hematomas and Complications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics, Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121002, P. R. China

Liaoning Provincial Collaborative Innovation Center for Medical Testing and Drug Research, Jinzhou Medical University, Jinzhou 010, P. R. China

Key Laboratory of Medical Tissue Engineering of Liaoning Province, Jinzhou Medical University, Jinzhou 010, P. R. China

Harbin Medical University, Harbin 150086, P. R. China

Cardiac Intensive Care Unit, Cardiovascular Hospital, Guangdong Second Provincial General Hospital, Guangzhou 510317, P. R. China

Integrated Chinese and Western Medicine Postdoctoral Research Station, School of Medicine, Jinan University, Guangzhou 510317, P. R. China

Department of Orthopedics, Jining No. 1 People’s Hospital, Jining 272111, P. R. China

Funding

Natural Science Foundation of Shandong Province · Postdoctoral workstation project of Guangdong Second People's Hospital

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