Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes

Özlem Şen; Melis Emanet; Martina Mazzuferi; Martina Bartolucci; Federico Catalano; Mirko Prato; Stefania Moscato; Attilio Marino; Daniele De Pasquale; Giammarino Pugliese; Francesco Bonaccorso; Vittorio Pellegrini; Antonio Esau Del Rio Castillo; Andrea Petretto; Gianni Ciofani

doi:10.1021/acsami.3c17097

journal article·2023-12-20Open access

Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes

Özlem Şen, Melis Emanet, Martina Mazzuferi, Martina Bartolucci, Federico Catalano, Mirko Prato, Stefania Moscato, Attilio Marino, Daniele De Pasquale, Giammarino Pugliese, Francesco Bonaccorso, Vittorio Pellegrini, Antonio Esau Del Rio Castillo, Andrea Petretto, Gianni Ciofani

ACS Applied Materials & Interfaces· Volume 15· Issue 50

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Source abstract

Abstract

Microglial cells play a critical role in glioblastoma multiforme (GBM) progression, which is considered a highly malignant brain cancer. The activation of microglia can either promote or inhibit GBM growth depending on the stage of the tumor development and on the microenvironment conditions. The current treatments for GBM have limited efficacy; therefore, there is an urgent need to develop novel and efficient strategies for drug delivery and targeting: in this context, a promising strategy consists of using nanoplatforms. This study investigates the microglial response and the therapeutic efficacy of dual-cell membrane-coated and doxorubicin-loaded hexagonal boron nitride nanoflakes tested on human microglia and GBM cells. Obtained results show promising therapeutic effects on glioma cells and an M2 microglia polarization, which refers to a specific phenotype or activation state that is associated with anti-inflammatory and tissue repair functions, highlighted through proteomic analysis.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Neuroinflammation and Neurodegeneration Mechanisms · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa 56025, Italy

Department of Mechanical & Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy

Core Facilities-Clinical Proteomics and Metabolomics, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, Genova 16147, Italy

Electron Microscopy Facility, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy

Materials Characterization Facility, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy

Nanochemistry, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy

BeDimensional SPA, Lungotorrente Secca 30R, Genova 16163, Italy

Graphene Laboratories, Istituto Italiano di Tecnologia, Via Morego 30, Genova 16163, Italy

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