journal article·2023-11-29

Enhancing NIR-II Imaging and Photothermal Therapy for Improved Oral Cancer Theranostics by Combining TICT and Aggregation-Induced Emission

Haitao Chen, Pingping Bao, Yonghui Lv, Rui Luo, Jiayin Deng, Yingbin Yan, Dan Ding, Heqi Gao

Publisher page

Abstract

In the treatment process of cancers like oral cancer, it is necessary to employ extensive surgical resection to achieve cancer eradication. However, this often results in damage to crucial functions such as chewing and speaking, leading to a poorer prognosis and a reduced quality of life. To address this issue, a multifunctional theranostic agent named MBPN-T-BTD has been developed by precisely modulating the excitation state energy distribution in the radiative/nonradiative decay pathways using the characteristics of twisted intramolecular charge transfer and aggregation-induced emission. This agent outperforms clinically utilized indocyanine green (ICG) in various aspects, including the second near-infrared window (NIR-II, 1000-1700 nm) fluorescence (FL) and photothermal conversion efficiency (PCE). Its nanoparticle form (BTB NPs) can be effectively used for high-contrast delineation of lymph node mapping and tongue and floor of mouth cancers using NIR-II FL, enabling surgeons to achieve more precise and thorough tumor clearance. For tumors located in close proximity to vital organs such as the tongue, the exceptional PCE (71.96%) of BTB NPs allows for targeted photothermal ablation with minimal damage to peripheral healthy tissues. This contribution provides a safer and more effective paradigm for minimally invasive or noninvasive treatment of oral cancer, ensuring the preservation of normal organ functions and showing potential for improving the overall prognosis and quality of life for cancer patients.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oromaxillofacial-Head and Neck Surgery, Tianjin Stomatological Hospital, The Affiliated Stomatological Hospital of Nankai University, Tianjin 300041, P. R. China

Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, P. R. China

Department of Endodontics, Tianjin Stomatological Hospital, The Affiliated Stomatological Hospital of Nankai University, Tianjin 300041, P. R. China

Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin 300071, P. R. China

School of Stomatology, Hospital of Stomatology, Tianjin Medical University, 12 Observatory Road, Tianjin 300070, P. R. China

College of Physics and Optoelectronic Engineering, College of Materials Science and Engineering, Center for AIE Research, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China

Funding

Science Fund for Distinguished Young Scholars of Tianjin Municipality · National Key Research and Development Program of China · National Natural Science Foundation of China · Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Stomatological Hospital · Tianjin Medical Talent Project · Tianjin Key Medical Discipline (Specialty) Construction Project

References (70)

Show source-provided references
1. 10.1038/s41392-022-00939-710.1038/s41392-022-00939-7 ↗
2. 10.1093/jnci/djz23810.1093/jnci/djz238 ↗
3. 10.1016/j.rpor.2012.06.00110.1016/j.rpor.2012.06.001 ↗
4. 10.1038/s41368-022-00210-310.1038/s41368-022-00210-3 ↗
5. 10.1016/j.oraloncology.2020.10465810.1016/j.oraloncology.2020.104658 ↗
6. 10.1016/j.cell.2022.06.01810.1016/j.cell.2022.06.018 ↗
7. 10.1080/10717544.2021.200067710.1080/10717544.2021.2000677 ↗
8. 10.1002/hed.2720710.1002/hed.27207 ↗
9. 10.1038/s41586-022-04898-510.1038/s41586-022-04898-5 ↗
10. 10.1002/hed.2681110.1002/hed.26811 ↗
11. 10.1002/ijc.3335210.1002/ijc.33352 ↗
12. 10.3390/cancers1419463010.3390/cancers14194630 ↗
13. 10.1038/s41368-023-00216-510.1038/s41368-023-00216-5 ↗
14. 10.1038/s41551-019-0494-010.1038/s41551-019-0494-0 ↗
15. 10.6023/A2010050110.6023/A20100501 ↗
16. 10.1021/acs.nanolett.8b0393610.1021/acs.nanolett.8b03936 ↗
17. 10.1038/s41467-019-10119-x10.1038/s41467-019-10119-x ↗
18. 10.1021/acsnano.2c1206610.1021/acsnano.2c12066 ↗
19. 10.1021/jacs.2c1007610.1021/jacs.2c10076 ↗
20. 10.1002/anie.20220261410.1002/anie.202202614 ↗
21. 10.1007/s10118-022-2793-210.1007/s10118-022-2793-2 ↗
22. 10.1021/acsnano.2c0553210.1021/acsnano.2c05532 ↗
23. 10.1021/acsnano.1c0755610.1021/acsnano.1c07556 ↗
24. 10.1002/smtd.20220158210.1002/smtd.202201582 ↗
25. 10.1021/acsnano.2c0355010.1021/acsnano.2c03550 ↗
26. 10.1021/jacs.2c0389510.1021/jacs.2c03895 ↗
27. 10.1021/jacs.2c0611110.1021/jacs.2c06111 ↗
28. 10.1002/anie.20220261410.1002/anie.202202614 ↗
29. 10.1002/anie.20200178310.1002/anie.202001783 ↗
30. 10.1021/ja300140c10.1021/ja300140c ↗
31. 10.1021/acs.chemrev.1c0055310.1021/acs.chemrev.1c00553 ↗
32. 10.1002/adma.20221045810.1002/adma.202210458 ↗
33. 10.1021/nn505554y10.1021/nn505554y ↗
34. 10.1038/s41467-021-26417-210.1038/s41467-021-26417-2 ↗
35. 10.1039/D0CS00664E10.1039/D0CS00664E ↗
36. 10.1021/acs.biomac.1c0151610.1021/acs.biomac.1c01516 ↗
37. 10.1002/advs.20170054210.1002/advs.201700542 ↗
38. 10.1021/acsami.7b1494310.1021/acsami.7b14943 ↗
39. 10.1016/j.bioactmat.2023.03.01610.1016/j.bioactmat.2023.03.016 ↗
40. 10.1002/adma.20200806110.1002/adma.202008061 ↗
41. 10.1002/adma.20200345810.1002/adma.202003458 ↗
42. 10.1002/anie.20221635110.1002/anie.202216351 ↗
43. 10.1002/anie.20200619110.1002/anie.202006191 ↗
44. 10.1002/adhm.20210106310.1002/adhm.202101063 ↗
45. 10.1002/anie.20200589910.1002/anie.202005899 ↗
46. 10.1021/jacs.8b1388910.1021/jacs.8b13889 ↗
47. 10.1039/D1TB02282B10.1039/D1TB02282B ↗
48. 10.1002/adhm.20210104310.1002/adhm.202101043 ↗
49. 10.1021/acsnano.8b0593710.1021/acsnano.8b05937 ↗
50. 10.1021/acsnano.2c0359710.1021/acsnano.2c03597 ↗
51. 10.1021/acsami.9b0317710.1021/acsami.9b03177 ↗
52. 10.1016/j.jcis.2021.04.00910.1016/j.jcis.2021.04.009 ↗
53. 10.1021/jacs.7b1033410.1021/jacs.7b10334 ↗
54. 10.1021/acsami.2c0230810.1021/acsami.2c02308 ↗
55. 10.1002/advs.20230110410.1002/advs.202301104 ↗
56. 10.1002/adhm.20210056910.1002/adhm.202100569 ↗
57. 10.1002/adma.20170598010.1002/adma.201705980 ↗
58. 10.1002/anie.20210904810.1002/anie.202109048 ↗
59. 10.1016/j.biomaterials.2020.12036510.1016/j.biomaterials.2020.120365 ↗
60. 10.1016/j.mtbio.2020.10008710.1016/j.mtbio.2020.100087 ↗
61. 10.1002/adma.20190295610.1002/adma.201902956 ↗
62. 10.1200/jco.20.0363710.1200/jco.20.03637 ↗
63. 10.1002/adma.20160666510.1002/adma.201606665 ↗
64. 10.3390/cancers1210305510.3390/cancers12103055 ↗
65. 10.1016/j.biomaterials.2022.12142510.1016/j.biomaterials.2022.121425 ↗
66. 10.1016/j.jconrel.2020.08.05510.1016/j.jconrel.2020.08.055 ↗
67. 10.1016/j.canlet.2018.10.04410.1016/j.canlet.2018.10.044 ↗
68. 10.1039/D2TB00775D10.1039/D2TB00775D ↗
69. 10.1002/adma.20220013910.1002/adma.202200139 ↗
70. 10.1038/s41467-019-08722-z10.1038/s41467-019-08722-z ↗