DataVXACS Applied Materials & InterfacesPaper
journal article·2023-01-18

Biomimetically Engineered Amyloid-Shelled Gold Nanocomplexes for Discovering α-Synuclein Oligomer-Degrading Drugs

Dongtak Lee, Hyo Gi Jung, Dongsung Park, Junho Bang, Ji Hye Hong, Sang Won Lee, Seokbeom Roh, Jae Won Jang, Yonghwan Kim, Kyo Seon Hwang, Young-Sun Lee, Jae-Yong Park, In Duk Jung, Jeong Hoon Lee, Gyudo Lee, Dae Sung Yoon

ACS Applied Materials & Interfaces· Volume 15· Issue 2
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Source abstract

Abstract

The assembly of α-synuclein (αS) oligomers is recognized as the main pathological driver of synucleinopathies. While the elimination of toxic αS oligomers shows promise for the treatment of Parkinson's disease (PD), the discovery of αS oligomer degradation drugs has been hindered by the lack of proper drug screening tools. Here, we report a drug screening platform for monitoring the efficacy of αS-oligomer-degrading drugs using amyloid-shelled gold nanocomplexes (ASGNs). We fabricate ASGNs in the presence of dopamine, mimicking the in vivo generation process of pathological αS oligomers. To test our platform, the first of its kind for PD drugs, we use αS-degrading proteases and various small molecular substances that have shown efficacy in PD treatment. We demonstrate that the ASGN-based in vitro platform has strong potential to discover effective αS-oligomer-targeting drugs, and thus it may reduce the attrition problem in drug discovery for PD treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Parkinson's Disease Mechanisms and Treatments · Alzheimer's disease research and treatments · Attention Deficit Hyperactivity Disorder

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering, Korea University, Seoul02841, South Korea

Interdisciplinary Program in Precision Public Health, Korea University, Seoul02841, South Korea

Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul02447, South Korea

Department of Biotechnology and Bioinformatics, Korea University, Sejong30019, South Korea

Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology, Korea University, Sejong30019, South Korea

ASTRION, 47, Gaeunsa-gil, Seongbuk-gu, Seoul02842, Republic of Korea

School of Biosystem and Biomedical Science, College of Health Science, Korea University, Seoul02841, Republic of Korea

Department of Electrical Engineering, Kwangwoon University, Seoul01897, South Korea

Funding

Korea Health Industry Development Institute · National Research Foundation of Korea · Korea University · BK21 Four Institute of Precision Public Health

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