DataVXACS Applied Materials & InterfacesPaper
journal article·2025-02-05Open access

Metal–Phenolic Nanomedicines Targeting Fatty Acid Metabolic Reprogramming to Overcome Immunosuppression in Radiometabolic Cancer Therapy

Guohao Wang, Dongmei Wang, Lu Xia, Jiabian Lian, Qing Zhang, Dongyan Shen, Zhanxiang Wang, Yunlu Dai

ACS Applied Materials & Interfaces· Volume 17· Issue 5
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Source abstract

Abstract

High Resolution Image Download MS PowerPoint Slide Radiation therapy (RT) is a prevalent cancer treatment; however, its therapeutic outcomes are frequently impeded by tumor radioresistance, largely attributed to metabolic reprogramming characterized by increased fatty acid uptake and oxidation. To overcome this limitation, we developed polyphenol–metal coordination polymer (PPWQ), a novel nanoradiotherapy sensitizer specifically designed to regulate fatty acid metabolism and improve RT efficacy. These nanoparticles (NPs) utilize a metal–phenolic network (MPN) to integrate tungsten ions (W 6+ ), quercetin (QR), and a PD-L1-blocking peptide within a PEG–polyphenol scaffold. When exposed to X-rays, PPWQ induces reactive oxygen species (ROS) to cause DNA damage, while QR inhibits CD36 expression, effectively curbing fatty acid uptake and mitigating immune evasion. In a 4T1 tumor-bearing mouse model, PPWQ demonstrated significant enhancement of RT by facilitating dendritic cell activation, boosting memory cytotoxic T lymphocytes, and skewing macrophages toward a pro-immune phenotype. These results underscore the potential of PPWQ to target metabolic vulnerabilities and advance the integration of immunotherapy with radiotherapy.
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Research context

PolymersNanomaterials

OpenAlex topics: Cancer, Lipids, and Metabolism · Cancer, Hypoxia, and Metabolism · RNA modifications and cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Xiamen Cell Therapy Research Center, The First Affiliated Hospital of Xiamen University, School of Medicine

Xiamen University

Department of Public Health and Medical Technology

Xiamen Medical College

Center for Precision Medicine, The First Affiliated Hospital, School of Medicine

Department of Laboratory Medicine, The First Affiliated Hospital, School of Medicine

Department of Cardiology, The First Affiliated Hospital of Xiamen University, School of Medicine

Department of Neurosurgery and Department of Neuroscience, Fujian Key Laboratory of Brain Tumors Diagnosis and Precision Treatment, Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University, School of Medicine

Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences

University of Macau

MoE Frontiers Science Center for Precision Oncology

Funding

Universidade de Macau · Natural Science Foundation of Xiamen Municipality · Fujian Provincial Health Technology Project · Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia · National Natural Science Foundation of China · Xiamen Cell Therapy Research Center · Xiamen City

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