Silicon–Carbon Dots-Loaded Mesoporous Silica Nanocomposites (mSiO₂@SiCDs): An Efficient Dual Inhibitor of Cu²⁺-Mediated Oxidative Stress and Aβ Aggregation for Alzheimer’s Disease

The redox-active metal ions, especially Cu 2+, are highly correlated to Alzheimer’s disease (AD) by causing metal ion-mediated oxidative stress and toxic metal-bound β-amyloid (Aβ) aggregates. Numerous pieces of evidence have revealed that the regulation of metal homeostasis could be an effective therapeutic strategy for AD. Herein, in virtue of the interaction of both amino-containing silane and ethylenediaminetetraacetic acid disodium salt for Cu 2+, the silicon–carbon dots (SiCDs) are deliberately prepared using these two raw materials as the cocarbon source; meanwhile, to realize the local enrichment of SiCDs and further maximize the chelating ability to Cu 2+, the SiCDs are feasibly loaded to the biocompatible mesoporous silica nanoparticles (mSiO 2 ) with the interaction between residual silane groups on SiCDs and silanol groups of mSiO 2 . Thus-obtained nanocomposites (i.e., mSiO 2 @SiCDs) could serve as an efficient Cu 2+ chelator with satisfactory metal selectivity and further modulate the enzymic activity of free Cu 2+ and the Aβ 42 –Cu 2+ complex to alleviate the pathological oxidative stress with an anti-inflammatory effect. Besides, mSiO 2 @SiCDs show an inspiring inhibitory effect on Cu 2+ -mediated Aβ aggregation and further protect the neural cells against the toxic Aβ 42 –Cu 2+ complex. Moreover, the transgenic Caenorhabditis elegans CL2120 assay demonstrates the protective efficacy of mSiO 2 @SiCDs on Cu 2+ -mediated Aβ toxicity in vivo, indicating its potential for AD treatment.