journal article·2022-06-29

Autonomous Bionanorobots via a Cage-Shaped Silsesquioxane Vehicle for In Vivo Heavy Metal Detoxification

Gang Wei, Yuanlong Gu, Naibo Lin, Xiaoyu Ning, Yong Lu, Gang Zhao, Shanyi Guang, Jihong Feng, Hongyao Xu

ACS Applied Materials & Interfaces· Volume 14· Issue 25
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Abstract

Nanorobots hold great promise for integrated drug delivery systems that are responsive to molecular triggers. Herein, we successfully developed an automatic smart bionanorobot that has transport capability and recognizes and removes zinc ions from poisoned cells based on nanoscale polyhedral oligomeric silsesquioxane molecules. This intelligent bionanorobot can easily move inside and outside the cell and find zinc ions owing to its highly selective recognition to zinc ions and high cell permeability, especially the well-combined high penetration and strong binding energy. More importantly, it was also found that this intelligent bionanorobot can restore round HeLa cells to a normal fusiform cell morphology following high-concentration zinc treatment and does not interfere with cell proliferation and division. It was also shown by in vivo experiments that the bionanorobot can inhibit persistent enlargement of the liver caused by zinc ion poisoning.
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Research context

OpenAlex topics: Micro and Nano Robotics · Advanced biosensing and bioanalysis techniques · Modular Robots and Swarm Intelligence

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, and College of Materials Science and Engineering & Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China

Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Hematology Oncology, Taizhou Municipal Hospital, No. 381, Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang, China

Research Institution for Biomimetics and Soft Matter, Fujian Key Provincial Laboratory for Soft Functional Materials Research, College of Materials, Xiamen University, 422 Siming Nan Road, Xiamen 361005, P. R. China

College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

Department of Oncology, Lishui People’s Hospital, Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China

Funding

Fujian Provincial Department of Science and Technology · Taizhou Municipal Science and Technology Bureau · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Zhejiang Provincial Health Planning Commission Fund

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