Gold-Decorated Silicon Nanowire Photocatalysts for Intracellular Production of Hydrogen Peroxide
Source abstract
Abstract
Hydrogen peroxide (H2O2) plays diverse biological roles, and its effects in part depend on its spatiotemporal presence, in both intra- and extracellular contexts. A full understanding of the physiological effects of H2O2 in both healthy and disease states is hampered by a lack of tools to controllably produce H2O2. Here, we address this issue by showing visible-light-induced production of exogenous H2O2 by free-standing, gold-decorated silicon nanowires internalized in human umbilical vein endothelial cells. We further show that the photocatalytic production of H2O2 is a general phenomenon of gold–silicon hybrid materials and is enhanced upon annealing.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States
Medical Scientist Training Program, University of Chicago, Chicago, Illinois 60637, United States
Department of Biophysical Sciences, University of Chicago, Chicago, Illinois 60637, United States
Pritzker School of Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States
The James Franck Institute, University of Chicago, Chicago, Illinois 60637, United States
The Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, United States
Funding
Army Research Office · National Institute of Allergy and Infectious Diseases · Air Force Office of Scientific Research · Office of Naval Research · Division of Civil, Mechanical and Manufacturing Innovation · Paul and Daisy Soros Foundation
References (89)
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