DataVXACS Applied Materials & InterfacesPaper
journal article·2024-12-11

Photothermal-Triggered Extracellular Matrix Clearance and Dendritic Cell Maturation for Enhanced Osteosarcoma Immunotherapy

Zhaolong Yu, Ziqi Gan, Wei Wu, Xiaojiang Sun, Xiaofei Cheng, Chen Chen, Bihui Cao, Zhongyi Sun, Jiwei Tian

ACS Applied Materials & Interfaces· Volume 16· Issue 49
Publisher page
Source abstract

Abstract

Osteosarcoma, a predominant malignant tumor among adolescents, exhibits high mortality and suboptimal immunotherapy efficacy due to a collagen-dense extracellular matrix (ECM) that hinders cytotoxic T lymphocyte (CTL) infiltration. Herein, we developed mesoporous polydopamine (MPDA) nanoparticles encapsulating bromelain and the immune adjuvant R848 (M@B/R), aimed at enhancing photothermal immunotherapy. These nanoparticles efficiently accumulate at the tumor site following injection. Upon near-infrared (NIR) light irradiation, photothermal therapy (PTT) induces immunogenic cell death in tumor cells and, with the aid of R848, efficiently promotes dendritic cell maturation, activating antitumor immunity and leading to CTL infiltration into the tumor. Concurrently, NIR-induced heating activates bromelain, resulting in ECM degradation and improved CTL penetration into the tumor. Our in vivo evaluations demonstrate potent antitumor effects in osteosarcoma-bearing mice. This integrated approach offers a promising strategy for overcoming physical barriers in ECM-rich tumors, marking a significant advancement in the treatment of osteosarcoma.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immunotherapy and Immune Responses · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China

Department of Hepato-Pancreato-Biliary & Gastric Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China

Department of Medical Oncology, the Sixth People’s Hospital of Luoyang, Luoyang 471000, P. R. China

Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China

Department of Orthopaedics, Shanghai Yida Hospital, Shanghai 201700, China

BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210019, China

Funding

Natural Science Foundation of Jiangsu Province · Shanghai Municipal Health Commission · Nanjing Medical Science and Technology Development fund

References (49)

Show source-provided references
1. 10.1038/s41572-022-00409-y10.1038/s41572-022-00409-y ↗
2. 10.1021/acsami.4c0301510.1021/acsami.4c03015 ↗
3. 10.1097/CORR.000000000000201110.1097/CORR.0000000000002011 ↗
4. 10.3390/cancers1411269410.3390/cancers14112694 ↗
5. 10.3390/cells1121350710.3390/cells11213507 ↗
6. 10.1016/j.ijpharm.2023.12263710.1016/j.ijpharm.2023.122637 ↗
7. 10.3390/ijms24221654510.3390/ijms242216545 ↗
8. 10.1021/acsami.3c1699510.1021/acsami.3c16995 ↗
9. 10.1021/acsami.5b0911210.1021/acsami.5b09112 ↗
10. 10.20517/cdr.2022.1810.20517/cdr.2022.18 ↗
11. 10.1038/s41590-022-01141-110.1038/s41590-022-01141-1 ↗
12. 10.1038/nature2518310.1038/nature25183 ↗
13. 10.1056/NEJMoa141108710.1056/NEJMoa1411087 ↗
14. 10.1126/sciadv.aay778510.1126/sciadv.aay7785 ↗
15. 10.1016/j.canlet.2022.21588710.1016/j.canlet.2022.215887 ↗
16. 10.1016/j.cell.2022.03.04110.1016/j.cell.2022.03.041 ↗
17. 10.1021/jacs.6b1138210.1021/jacs.6b11382 ↗
18. 10.1002/adma.20220013910.1002/adma.202200139 ↗
19. 10.1038/s41392-024-01852-x10.1038/s41392-024-01852-x ↗
20. 10.1016/j.biomaterials.2022.12138310.1016/j.biomaterials.2022.121383 ↗
21. 10.1039/D2BM01900K10.1039/D2BM01900K ↗
22. 10.1021/acsami.2c1824410.1021/acsami.2c18244 ↗
23. 10.1021/acs.nanolett.9b0290310.1021/acs.nanolett.9b02903 ↗
24. 10.1002/adma.20230190110.1002/adma.202301901 ↗
25. 10.1016/j.actbio.2022.12.01810.1016/j.actbio.2022.12.018 ↗
26. 10.1016/j.jconrel.2023.02.02910.1016/j.jconrel.2023.02.029 ↗
27. 10.1016/j.actbio.2023.08.00710.1016/j.actbio.2023.08.007 ↗
28. 10.1002/anie.20180051110.1002/anie.201800511 ↗
29. 10.1016/j.colsurfb.2024.11393710.1016/j.colsurfb.2024.113937 ↗
30. 10.1016/j.bioactmat.2022.01.05010.1016/j.bioactmat.2022.01.050 ↗
31. 10.1038/s41467-021-21047-010.1038/s41467-021-21047-0 ↗
32. 10.1021/acsami.4c0604810.1021/acsami.4c06048 ↗
33. 10.3892/ol.2016.471410.3892/ol.2016.4714 ↗
34. 10.3390/cancers1302036010.3390/cancers13020360 ↗
35. 10.1016/j.actbio.2024.01.00910.1016/j.actbio.2024.01.009 ↗
36. 10.1002/smll.20231056510.1002/smll.202310565 ↗
37. 10.1016/j.biomaterials.2019.11947910.1016/j.biomaterials.2019.119479 ↗
38. 10.1021/acsnano.9b0987110.1021/acsnano.9b09871 ↗
39. 10.1002/smll.20230958310.1002/smll.202309583 ↗
40. 10.1016/j.jconrel.2020.01.04810.1016/j.jconrel.2020.01.048 ↗
41. 10.1021/acs.nanolett.2c0050010.1021/acs.nanolett.2c00500 ↗
42. 10.1021/acsnano.3c0300510.1021/acsnano.3c03005 ↗
43. 10.34133/2022/981627210.34133/2022/9816272 ↗
44. 10.1016/j.bioactmat.2022.07.02710.1016/j.bioactmat.2022.07.027 ↗
45. 10.1016/j.nantod.2022.10149010.1016/j.nantod.2022.101490 ↗
46. 10.1002/agt2.47610.1002/agt2.476 ↗
47. 10.1002/smll.20230467510.1002/smll.202304675 ↗
48. 10.1002/smll.20200811410.1002/smll.202008114 ↗
49. 10.1007/s10118-022-2794-110.1007/s10118-022-2794-1 ↗