journal article·2024-06-26

3D Printed Pedicle Screws with Microarc Oxidation Ceramic Interfaces Enhance Osteointegration and Orthopedic Fixation Feasibility

Zehao Chen, Binghao Wang, Chengliang Yang, Zhendong Lv, Yu Wei, Tianming Pan, Fuqing Xuan, Xingdie Zhou, Hao Chen, Hongxing Shen, Liqiang Wang, Yuhui Zhang

ACS Applied Materials & Interfaces· Volume 16· Issue 25
Publisher page

Abstract

Effective osteointegration is of great importance for pedicle screws in spinal fusion surgeries. However, the lack of osteoinductive activity of current screws diminishes their feasibility for osteointegration and fixation, making screw loosening a common complication worldwide. In this study, Ti-6Al-4V pedicle screws with full through-hole design were fabricated via selective laser melting (SLM) 3D printing and then deposited with porous oxide coatings by microarc oxidation (MAO). The porous surface morphology of the oxide coating and the release of bioactive ions could effectively support cell adhesion, migration, vascularization, and osteogenesis in vitro . Furthermore, an in vivo goat model demonstrated the efficacy of modified screws in improving bone maturation and osseointegration, thus providing a promising method for feasible orthopedic internal fixation.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Facial Trauma and Fracture Management · Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Spine Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai 200434, China

Guangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative Diseases, Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative Diseases, Affiliated Hospital of Youjiang Medical University, Baise, Guangxi 533000, China

State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China

Danyang Hospital of Traditional Chinese Medicine, Jiangsu 212300, China

School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China

School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China

Funding

Milstein Medical Asian American Partnership Foundation · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Shanghai Fourth People's Hospital

References (58)

Show source-provided references
1. 10.1056/NEJMoa210099010.1056/NEJMoa2100990 ↗
2. 10.1016/S0140-6736(21)00733-910.1016/S0140-6736(21)00733-9 ↗
3. 10.1016/j.spinee.2017.04.02910.1016/j.spinee.2017.04.029 ↗
4. 10.1016/j.spinee.2020.08.00210.1016/j.spinee.2020.08.002 ↗
5. 10.1016/j.spinee.2017.01.00910.1016/j.spinee.2017.01.009 ↗
6. 10.1016/j.biomaterials.2020.11982910.1016/j.biomaterials.2020.119829 ↗
7. 10.1002/adem.20190125810.1002/adem.201901258 ↗
8. 10.1016/j.mtbio.2022.10031510.1016/j.mtbio.2022.100315 ↗
9. 10.1016/j.biomaterials.2017.12.00710.1016/j.biomaterials.2017.12.007 ↗
10. 10.1021/acsbiomaterials.8b0026110.1021/acsbiomaterials.8b00261 ↗
11. 10.1016/j.colsurfb.2017.08.05910.1016/j.colsurfb.2017.08.059 ↗
12. 10.1002/jor.2377110.1002/jor.23771 ↗
13. 10.1016/j.matdes.2015.07.08610.1016/j.matdes.2015.07.086 ↗
14. 10.1016/j.jallcom.2023.16977310.1016/j.jallcom.2023.169773 ↗
15. 10.1097/CORR.000000000000224010.1097/CORR.0000000000002240 ↗
16. 10.1002/jor.2471110.1002/jor.24711 ↗
17. 10.1002/adem.20180121510.1002/adem.201801215 ↗
18. 10.1016/j.pmatsci.2024.10127710.1016/j.pmatsci.2024.101277 ↗
19. 10.1016/j.ijplas.2024.10388410.1016/j.ijplas.2024.103884 ↗
20. 10.1016/j.jmst.2023.11.00310.1016/j.jmst.2023.11.003 ↗
21. 10.1016/j.jmst.2023.10.05310.1016/j.jmst.2023.10.053 ↗
22. 10.36922/ijb.256510.36922/ijb.2565 ↗
23. 10.1016/j.actamat.2015.06.00410.1016/j.actamat.2015.06.004 ↗
24. 10.1016/j.jmapro.2022.11.04610.1016/j.jmapro.2022.11.046 ↗
25. 10.1007/s40195-023-01644-210.1007/s40195-023-01644-2 ↗
26. 10.1080/21663831.2024.234193710.1080/21663831.2024.2341937 ↗
27. 10.1016/j.jmrt.2023.07.23310.1016/j.jmrt.2023.07.233 ↗
28. 10.1016/j.actamat.2022.11829510.1016/j.actamat.2022.118295 ↗
29. 10.1016/j.jmrt.2022.10.16010.1016/j.jmrt.2022.10.160 ↗
30. 10.1007/s10856-015-5533-010.1007/s10856-015-5533-0 ↗
31. 10.1016/j.surfcoat.2022.12904510.1016/j.surfcoat.2022.129045 ↗
32. 10.1016/j.apsusc.2011.01.05710.1016/j.apsusc.2011.01.057 ↗
33. 10.1016/j.apsusc.2019.02.14210.1016/j.apsusc.2019.02.142 ↗
34. 10.1002/btm2.1023910.1002/btm2.10239 ↗
35. Balshe A. A. · Int. J. Oral. Maxillofac. Implants · 2009 · 24 · 1113
36. 10.1016/j.actbio.2018.11.01810.1016/j.actbio.2018.11.018 ↗
37. 10.1126/sciadv.abg381610.1126/sciadv.abg3816 ↗
38. 10.1016/j.biomaterials.2003.09.04810.1016/j.biomaterials.2003.09.048 ↗
39. 10.1002/EXP.2021010510.1002/EXP.20210105 ↗
40. 10.1016/j.surfcoat.2004.10.14610.1016/j.surfcoat.2004.10.146 ↗
41. 10.3390/ijms2202049710.3390/ijms22020497 ↗
42. 10.1002/adhm.20200159110.1002/adhm.202001591 ↗
43. 10.1016/j.bioactmat.2022.09.01410.1016/j.bioactmat.2022.09.014 ↗
44. 10.1039/D1NR02459K10.1039/D1NR02459K ↗
45. 10.1002/adma.20231087610.1002/adma.202310876 ↗
46. 10.1021/acsami.2c1080910.1021/acsami.2c10809 ↗
47. 10.1002/smsc.20230002710.1002/smsc.202300027 ↗
48. 10.1002/anbr.20220011410.1002/anbr.202200114 ↗
49. 10.1016/j.biomaterials.2018.10.03310.1016/j.biomaterials.2018.10.033 ↗
50. 10.1016/j.critrevonc.2015.05.01010.1016/j.critrevonc.2015.05.010 ↗
51. 10.1093/rb/rbad06210.1093/rb/rbad062 ↗
52. 10.1002/jsp2.116210.1002/jsp2.1162 ↗
53. 10.1016/j.jot.2022.10.00610.1016/j.jot.2022.10.006 ↗
54. 10.1021/acs.nanolett.9b0476110.1021/acs.nanolett.9b04761 ↗
55. 10.1002/smll.20190542210.1002/smll.201905422 ↗
56. 10.1016/j.msec.2021.11243710.1016/j.msec.2021.112437 ↗
57. 10.1021/acs.langmuir.5b0424510.1021/acs.langmuir.5b04245 ↗
58. 10.1016/j.bioactmat.2016.09.00110.1016/j.bioactmat.2016.09.001 ↗