journal article·2024-06-05Open access

Upconverting Nanoparticles Coated with Light-Breakable Mesoporous Silica for NIR-Triggered Release of Hydrophobic Molecules

Vivienne Tam, Pierre Picchetti, Yiwei Liu, Artiom Skripka, Marco Carofiglio, Giulia Tamboia, Arianna Bresci, Francesco Manetti, Giulio Cerullo, Dario Polli, Luisa De Cola, Fiorenzo Vetrone, Marta Cerruti

ACS Applied Materials & Interfaces· Volume 16· Issue 22
Publisher page

Abstract

Upconverting nanoparticles (UCNPs) doped with Yb 3+ and Tm 3+ are near-infrared (NIR) to ultraviolet (UV) transducers that can be used for NIR-controlled drug delivery. However, due to the low quantum yield of upconversion, high laser powers and long irradiation times are required to trigger this drug release. In this work, we report the one-step synthesis of a nanocomposite consisting of a LiYbF 4:Tm 3+ @LiYF 4 UCNP coated with mesoporous UV-breakable organosilica shells of various thicknesses. We demonstrate that a thin shell accelerates the breakage of the shell at 1 W/cm 2 NIR light exposure, a laser power up to 9 times lower than that of conventional systems. When the mesopores are loaded with hydrophobic vitamin D 3 precursor 7-dehydrocholesterol (7-DH), shell breakage results in subsequent cargo release. Its minimal toxicity in HeLa cells and successful internalization into the cell cytoplasm demonstrate its biocompatibility and potential application in biological systems. The tunability of this system due to its simple, one-step synthesis process and its ability to operate at low laser powers opens up avenues in UCNP-powered NIR-triggered drug delivery toward a more scalable, flexible, and ultimately translational option.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Gas Sensing Nanomaterials and Sensors · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Mining and Materials Engineering, McGill University, 3610 Rue University, Montreal, Quebec H3A 0C5, Canada

Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology (INT), Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

Centre Énergie, Matériaux et Télécommunications, Institut National de la Recherche Scientifique, Université du Québec, 1650 Boul. Lionel Boulet, Varennes, Québec J3X 1P7, Canada

Nanomaterials for Bioimaging Group, Departamento de Fiśica de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid 28049, Spain

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri “IRCCS”, Via Mario Negri 2, 20156 Milan, Italy

Department of Pharmaceutical Sciences, DISFARM, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, Italy

Department of Chemistry, Biology and Biotechnology, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy

Department of Physics, Politecnico di Milano, P.zza Leonardo da Vinci 32, 20133 Milan, Italy

CNR-Institute for Photonics and Nanotechnologies (IFN-CNR), P.zza Leonardo Da Vinci 32, 20133 Milan, Italy

Funding

Faculty of Engineering, McGill University · Fonds de recherche du Québec – Nature et technologies · Canada Research Chairs · Natural Sciences and Engineering Research Council of Canada · Mitacs · Vanier Canada Graduate Scholarship

References (70)

Show source-provided references
1. 10.1002/adfm.20200502910.1002/adfm.202005029 ↗
2. 10.1016/j.jconrel.2015.07.01810.1016/j.jconrel.2015.07.018 ↗
3. 10.1021/cr400425h10.1021/cr400425h ↗
4. 10.1016/j.cbpa.2003.08.00710.1016/j.cbpa.2003.08.007 ↗
5. 10.1117/1.295797010.1117/1.2957970 ↗
6. 10.1021/nn302972r10.1021/nn302972r ↗
7. 10.1039/C6CS00415F10.1039/C6CS00415F ↗
8. 10.3184/00368500578323843510.3184/003685005783238435 ↗
9. 10.1117/1.JBO.19.7.07050110.1117/1.JBO.19.7.070501 ↗
10. 10.1021/acsnano.5b0787310.1021/acsnano.5b07873 ↗
11. 10.1021/nn200110j10.1021/nn200110j ↗
12. 10.1021/ja407500210.1021/ja4075002 ↗
13. 10.1021/jacs.7b0022310.1021/jacs.7b00223 ↗
14. 10.1021/jacs.8b0708610.1021/jacs.8b07086 ↗
15. 10.1021/jacs.8b0397710.1021/jacs.8b03977 ↗
16. 10.1021/acsami.8b0506310.1021/acsami.8b05063 ↗
17. 10.1021/acsami.8b0445510.1021/acsami.8b04455 ↗
18. 10.1021/jacs.9b1278810.1021/jacs.9b12788 ↗
19. 10.1039/c2cs15344k10.1039/c2cs15344k ↗
20. 10.1021/ja102595j10.1021/ja102595j ↗
21. 10.1021/bm401670t10.1021/bm401670t ↗
22. 10.1002/adma.20160463410.1002/adma.201604634 ↗
23. 10.1002/anie.20060448810.1002/anie.200604488 ↗
24. 10.1002/anie.20130018310.1002/anie.201300183 ↗
25. 10.1002/smll.20120176510.1002/smll.201201765 ↗
26. 10.1002/adfm.20130213310.1002/adfm.201302133 ↗
27. 10.1021/acs.jpcb.9b0187010.1021/acs.jpcb.9b01870 ↗
28. 10.1021/jacs.5b1235710.1021/jacs.5b12357 ↗
29. 10.1038/natrevmats.2016.7110.1038/natrevmats.2016.71 ↗
30. 10.1080/17425247.2017.124529010.1080/17425247.2017.1245290 ↗
31. 10.1021/acs.chemmater.9b0393710.1021/acs.chemmater.9b03937 ↗
32. 10.1039/C2BM00087C10.1039/C2BM00087C ↗
33. 10.1021/ja061848b10.1021/ja061848b ↗
34. 10.1002/adma.20090117410.1002/adma.200901174 ↗
35. 10.1021/jacs.8b0145810.1021/jacs.8b01458 ↗
36. 10.1039/C7NR02124K10.1039/C7NR02124K ↗
37. 10.1002/chem.20110259910.1002/chem.201102599 ↗
38. 10.1039/C4TC02791D10.1039/C4TC02791D ↗
39. 10.1039/C9NR03127H10.1039/C9NR03127H ↗
40. 10.1039/C5NR02100F10.1039/C5NR02100F ↗
41. 10.1016/j.jpowsour.2013.07.09910.1016/j.jpowsour.2013.07.099 ↗
42. 10.1021/nl071928t10.1021/nl071928t ↗
43. 10.1039/C9AN01080G10.1039/C9AN01080G ↗
44. 10.1063/1.502708010.1063/1.5027080 ↗
45. 10.1021/ma201924h10.1021/ma201924h ↗
46. 10.1002/adfm.20180710510.1002/adfm.201807105 ↗
47. 10.1021/jacs.7b1367710.1021/jacs.7b13677 ↗
48. 10.1021/acsnano.7b0739310.1021/acsnano.7b07393 ↗
49. 10.1038/s41586-022-04485-810.1038/s41586-022-04485-8 ↗
50. 10.1126/science.aaq114410.1126/science.aaq1144 ↗
51. 10.1039/C8QM00438B10.1039/C8QM00438B ↗
52. 10.1021/ja025573l10.1021/ja025573l ↗
53. 10.1016/j.micromeso.2021.11141110.1016/j.micromeso.2021.111411 ↗
54. 10.1016/j.micromeso.2011.12.01710.1016/j.micromeso.2011.12.017 ↗
55. 10.1021/acs.chemmater.9b0022110.1021/acs.chemmater.9b00221 ↗
56. 10.1016/j.apcatb.2012.07.01810.1016/j.apcatb.2012.07.018 ↗
57. 10.3390/ma1312277710.3390/ma13122777 ↗
58. 10.1021/cr300177k10.1021/cr300177k ↗
59. 10.1039/C8OB01330F10.1039/C8OB01330F ↗
60. 10.3390/nano1105129310.3390/nano11051293 ↗
61. 10.1039/C5NR02100F10.1039/C5NR02100F ↗
62. 10.1039/C4CS00187G10.1039/C4CS00187G ↗
63. 10.1002/smll.20220071010.1002/smll.202200710 ↗
64. 10.1021/acsami.1c1061810.1021/acsami.1c10618 ↗
65. 10.1002/adma.20110476310.1002/adma.201104763 ↗
66. 10.1016/j.addr.2012.07.01810.1016/j.addr.2012.07.018 ↗
67. 10.1016/j.surfrep.2014.07.00110.1016/j.surfrep.2014.07.001 ↗
68. 10.1002/anie.20130018310.1002/anie.201300183 ↗
69. 10.1021/acs.chemmater.1c0444710.1021/acs.chemmater.1c04447 ↗
70. Fedele D. · Energy Health · 2010 · 06 · 10