Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications
Source abstract
Abstract
Electrohydrodynamic atomization (EHDA) provides unparalleled control over the size and production rate of particles from solution. However, conventional methods produce highly charged particles that are not appropriate for inhalation drug delivery. We present a self-propelled EHDA system to address this challenge, a promising one-step platform for generating and delivering charge-reduced particles. Our approach uses a sharp electrode to produce ion wind, which reduces the cumulative charge in the particles and transports them to a target in front of the nozzle. We effectively controlled the morphologies of polymer products created from poly(vinylidene fluoride) (PVDF) at various concentrations. Our technique has also been proven safe for bioapplications, as evidenced by the delivery of PVDF particles onto breast cancer cells. The combination of simultaneous particle production and charge reduction, along with its direct delivery capability, makes the self-propelled EHDA a versatile technique for drug delivery applications.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrohydrodynamics and Fluid Dynamics · Aerosol Filtration and Electrostatic Precipitation · Fluid Dynamics and Heat Transfer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Engineering and Built Environment, Griffith University, Gold Coast, QLD 4215, Australia
Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane, QLD 4111, Australia
School of Mechanical and Electrical Engineering, University of Southern Queensland, Toowoomba, QLD 4350, Australia
School of Engineering, University of Tokyo, Tokyo 113-8656, Japan
School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4067, Australia
School of Environment and Science, Griffith University, Brisbane, QLD 4211, Australia
Centre for Catalysis and Clean Energy, Griffith University, Gold Coast, QLD 4215, Australia
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